|Title||Long-term association between self-reported signs and symptoms and heart failure hospitalizations: the Atherosclerosis Risk In Communities (ARIC) Study.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Avery CL, Mills KT, Chambless LE, Chang PP, Folsom AR, Mosley TH, Ni H, Rosamond WD, Wagenknecht L, Wood J, Heiss G|
|Journal||Eur J Heart Fail|
|Date Published||2010 Mar|
|Keywords||African Americans, Cohort Studies, European Continental Ancestry Group, Female, Health Status Indicators, Heart Failure, Hospitalization, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Population Surveillance, Proportional Hazards Models, Prospective Studies, Risk Assessment, Risk Factors, Self-Assessment, Surveys and Questionnaires, Time Factors, United States|
AIMS: Although studies of the accuracy of heart failure (HF) classification scoring systems are available, few have examined their performance when restricted to self-reported items.
METHODS AND RESULTS: We evaluated the association between a simplified version of the Gothenburg score, a validated HF score comprised of cardiac and pulmonary signs and symptoms and medication use, and incident HF hospitalizations in 15,430 Atherosclerosis Risk in Communities (ARIC) Study participants. Gothenburg scores (range: 0-3) were constructed using self-reported items obtained at study baseline (1987-89). Incident HF hospitalization over 14.7 years of follow-up was defined as the first identified hospitalization with an ICD-9 discharge code of 428 (n = 1,668). Self-reported Gothenburg scores demonstrated very high agreement with the original metric comprised of self-reported and clinical measures and were directly associated with incident HF hospitalizations: [score = 1: hazard rate ratio (HRR) = 1.23 (1.07-1.42); score = 2: HRR = 2.17 (1.92-2.43); score = 3: HRR = 3.98 (3.37-4.70)].
CONCLUSION: In a population-based cohort, self-reported Gothenburg criteria items were associated with hospitalized HF over a prolonged follow-up time. The association was also consistent across groups defined by sex and race, suggesting that this simple score deserves further study as a screening tool for the identification of individuals at high risk of HF in resource-limited settings.
|Alternate Journal||Eur J Heart Fail|
|PubMed Central ID||PMC2821798|
|Grant List||N01-HC-55022 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States