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Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

TitleDipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2010
AuthorsLuft VC, Schmidt M I, Pankow JS, Hoogeveen RC, Couper D, Heiss G, Duncan BB
Corporate AuthorsAtherosclerosis Risk in Communities Investigators
JournalDiabetes Care
Volume33
Issue5
Pagination1109-11
Date Published2010 May
ISSN1935-5548
KeywordsAtherosclerosis, Diabetes Mellitus, Type 2, Dipeptidyl Peptidase 4, Fasting, Female, Humans, Incidence, Inflammation, Male, Middle Aged, Predictive Value of Tests, Proportional Hazards Models, Risk Factors, Smoking
Abstract

OBJECTIVE: Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes.

RESEARCH DESIGN AND METHODS: Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over approximately 9 years within the Atherosclerosis Risk in Communities study.

RESULTS: In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations

CONCLUSIONS: Fasting DPP-IV levels do not appear to predict incident diabetes.

DOI10.2337/dc09-1996
Alternate JournalDiabetes Care
PubMed ID20185737
PubMed Central IDPMC2858185
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
R01-DK-56918 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R01 DK056918 / DK / NIDDK NIH HHS / United States