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Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleRisk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2010
AuthorsMatsushita K, Selvin E, Bash LD, Astor BC, Coresh J
JournalAm J Kidney Dis
Volume55
Issue4
Pagination648-59
Date Published2010 Apr
ISSN1523-6838
KeywordsCause of Death, Chronic Disease, Coronary Disease, Female, Glomerular Filtration Rate, Humans, Kidney Diseases, Kidney Failure, Chronic, Male, Mathematics, Middle Aged, Prospective Studies, Risk Assessment, Stroke
Abstract

BACKGROUND: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) recently published an equation for estimated glomerular filtration rate (eGFR) using the same variables (serum creatinine level, age, sex, and race) as the Modification of Diet in Renal Disease (MDRD) Study equation. Although the CKD-EPI equation estimates GFR more precisely compared with the MDRD Study equation, whether this equation improves risk prediction is unknown.

STUDY DESIGN: Prospective cohort study, the Atherosclerosis Risk in Communities (ARIC) Study.

SETTING & PARTICIPANTS: 13,905 middle-aged participants without a history of cardiovascular disease with median follow-up of 16.9 years.

PREDICTOR: eGFR.

OUTCOMES & MEASUREMENTS: We compared the association of eGFR in categories (>or=120, 90-119, 60-89, 30-59, and

RESULTS: The median value for eGFR(CKD-EPI) was higher than that for eGFR(MDRD) (97.6 vs 88.8 mL/min/1.73 m(2); P

LIMITATIONS: Limited number of cases with eGFR

CONCLUSIONS: The CKD-EPI equation more appropriately categorized individuals with respect to long-term clinical risk compared with the MDRD Study equation, suggesting improved clinical usefulness in this middle-aged population.

DOI10.1053/j.ajkd.2009.12.016
Alternate JournalAm J Kidney Dis
PubMed ID20189275
PubMed Central IDPMC2858455
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01 HC055022 / HC / NHLBI NIH HHS / United States
R01 DK076770-03S1 / DK / NIDDK NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
K01 DK076595-03 / DK / NIDDK NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
K01 DK076595-04 / DK / NIDDK NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
R01 DK076770-02 / DK / NIDDK NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
T32 HL007024-24S1 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
R01 DK076770-01 / DK / NIDDK NIH HHS / United States
R01DK076770 / DK / NIDDK NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
K01 DK076595-01 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R01 DK076770 / DK / NIDDK NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
N01 HC055021 / HC / NHLBI NIH HHS / United States
R01 DK076770-01S1 / DK / NIDDK NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
K01DK076595 / DK / NIDDK NIH HHS / United States
R01 DK076770-03 / DK / NIDDK NIH HHS / United States
K01 DK076595-02 / DK / NIDDK NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
R01 DK076770-04 / DK / NIDDK NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
T32HL07024 / HL / NHLBI NIH HHS / United States
N01 HC055016 / HC / NHLBI NIH HHS / United States