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Intercellular adhesion molecule-1 G241R polymorphism predicts risk of incident ischemic stroke: Atherosclerosis Risk in Communities study.

TitleIntercellular adhesion molecule-1 G241R polymorphism predicts risk of incident ischemic stroke: Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2010
AuthorsVolcik KA, Ballantyne CM, Hoogeveen R, Folsom AR, Boerwinkle E
JournalStroke
Volume41
Issue5
Pagination1038-40
Date Published2010 May
ISSN1524-4628
KeywordsAtherosclerosis, Brain Ischemia, Female, Follow-Up Studies, Humans, Incidence, Intercellular Adhesion Molecule-1, Male, Middle Aged, Polymorphism, Genetic, Predictive Value of Tests, Prospective Studies, Residence Characteristics, Risk Factors, Stroke
Abstract

BACKGROUND AND PURPOSE: ICAM-1 levels are increased in pathological studies of atherosclerosis. We evaluated 13,491 participants from the Atherosclerosis Risk in Communities study to determine the association of ICAM-1 G241R and K469E polymorphisms with incident CHD and ischemic stroke.

METHODS: Incidences of ischemic stroke (N=517) and CHD (N=1,629) through 2003 were determined by annual telephone calls and hospital and death certificate surveillance. Risk factors were measured at the baseline exam. Cox proportional hazards models were used to estimate HRRs.

RESULTS: The ICAM-1 G241RR genotype was associated with significantly increased risk of ischemic stroke in both whites (HRR=2.18(1.01-4.68), P=0.05) and African Americans (HRR=7.04(3.72-13.3), P

CONCLUSIONS: The ICAM-1 241RR genotype is associated with increased risk of incident ischemic stroke in both whites and African Americans.

DOI10.1161/STROKEAHA.109.575563
Alternate JournalStroke
PubMed ID20360547
PubMed Central IDPMC3036988
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States