Pulse lineResearch With Heart Logo

Demographic and cardiovascular risk factors modify association of fasting insulin with incident coronary heart disease and ischemic stroke (from the Atherosclerosis Risk In Communities Study).

TitleDemographic and cardiovascular risk factors modify association of fasting insulin with incident coronary heart disease and ischemic stroke (from the Atherosclerosis Risk In Communities Study).
Publication TypeJournal Article
Year of Publication2010
AuthorsRasmussen-Torvik LJ, Yatsuya H, Selvin E, Alonso A, Folsom AR
JournalAm J Cardiol
Volume105
Issue10
Pagination1420-5
Date Published2010 May 15
ISSN1879-1913
KeywordsAfrican Continental Ancestry Group, Age Distribution, Blood Glucose, Cohort Studies, Confidence Intervals, Coronary Disease, European Continental Ancestry Group, Fasting, Female, Humans, Incidence, Insulin, Male, Middle Aged, Probability, Prognosis, Proportional Hazards Models, Risk Assessment, Sex Distribution, Stroke, United States
Abstract

Previous studies have reported an association between circulating insulin and incident cardiovascular disease, but limited knowledge is available on the association across subgroups. We examined the associations of fasting insulin with incident coronary heart disease (CHD) and ischemic stroke in multiple subgroups of a biracial, middle-age cohort. A total of 12,323 subjects were included in the analysis. The incidence of CHD (n = 960) and ischemic stroke (n = 445) through 2005 was determined through annual interviews, repeat examinations, and community surveillance. Serum insulin was measured at baseline. Cox regression analysis was used to estimate the hazard ratios by quintile of fasting insulin at baseline and to determine the significance of effect modification. In the minimally adjusted models (age, gender, race, and field center), the baseline fasting insulin quintile was positively associated with both incident CHD (hazard ratio per quintile insulin = 1.12, p-trend

DOI10.1016/j.amjcard.2009.12.065
Alternate JournalAm J Cardiol
PubMed ID20451688
PubMed Central IDPMC2883917
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
T32 HL007779-09 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
HL07779 / HL / NHLBI NIH HHS / United States