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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

TitleTwelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Publication TypeJournal Article
Year of Publication2010
AuthorsVoight BF, Scott LJ, Steinthorsdottir V, et al.
Corporate AuthorsMAGIC Investigators, GIANT consortium
JournalNat Genet
Volume42
Issue7
Pagination579-89
Date Published2010 Jul
ISSN1546-1718
KeywordsBlood Glucose, Diabetes Mellitus, Type 2, Dual-Specificity Phosphatases, Fasting, Gene Dosage, Gene Expression Profiling, Genetic Heterogeneity, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Hepatocyte Nuclear Factor 1-alpha, Humans, KCNQ1 Potassium Channel, Meta-Analysis as Topic, Mitogen-Activated Protein Kinase Phosphatases, Polymorphism, Single Nucleotide
Abstract

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P

DOI10.1038/ng.609
Alternate JournalNat Genet
PubMed ID20581827
PubMed Central IDPMC3080658
Grant ListR01 DK058845 / DK / NIDDK NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
086596 / WT_ / Wellcome Trust / United Kingdom
R01HL087641 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
MC_U127592696 / MRC_ / Medical Research Council / United Kingdom
G0601261 / MRC_ / Medical Research Council / United Kingdom
R01HL086694 / HL / NHLBI NIH HHS / United States
N01HC55020 / HL / NHLBI NIH HHS / United States
R01 DK078616 / DK / NIDDK NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
CZB/4/710 / CSO_ / Chief Scientist Office / United Kingdom
R01 DK073490 / DK / NIDDK NIH HHS / United States
K08 AR055688-03 / AR / NIAMS NIH HHS / United States
R56 DK062370 / DK / NIDDK NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
G0600331 / MRC_ / Medical Research Council / United Kingdom
079557 / WT_ / Wellcome Trust / United Kingdom
R01HL59367 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
088885 / WT_ / Wellcome Trust / United Kingdom
R01 HL059367 / HL / NHLBI NIH HHS / United States
075491 / WT_ / Wellcome Trust / United Kingdom
K23-DK65978 / DK / NIDDK NIH HHS / United States
G0700222(81696) / MRC_ / Medical Research Council / United Kingdom
N01-HC-55016 / HC / NHLBI NIH HHS / United States
U01 HG004171 / HG / NHGRI NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
DK58845 / DK / NIDDK NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
DK069922 / DK / NIDDK NIH HHS / United States
U01HG004399 / HG / NHGRI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
DHCS/07/07/008 / DH_ / Department of Health / United Kingdom
N01HC55015 / HL / NHLBI NIH HHS / United States
077016 / WT_ / Wellcome Trust / United Kingdom
1K08AR055688 / AR / NIAMS NIH HHS / United States
083270 / WT_ / Wellcome Trust / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
072960 / WT_ / Wellcome Trust / United Kingdom
K99 HL094535 / HL / NHLBI NIH HHS / United States
076113 / WT_ / Wellcome Trust / United Kingdom
DK072193 / DK / NIDDK NIH HHS / United States
MC_U106179471 / MRC_ / Medical Research Council / United Kingdom
K24-DK080140 / DK / NIDDK NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
G0701863 / MRC_ / Medical Research Council / United Kingdom
Z01 HG000024 / ImNIH / Intramural NIH HHS / United States
K24 DK080140 / DK / NIDDK NIH HHS / United States
090532 / WT_ / Wellcome Trust / United Kingdom
N01-HC-55020 / HC / NHLBI NIH HHS / United States
U01HG004171 / HG / NHGRI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
MC_U106179474 / MRC_ / Medical Research Council / United Kingdom
U01 DK078616 / DK / NIDDK NIH HHS / United States
1K99HL094535-01A1 / HL / NHLBI NIH HHS / United States
DK078616 / DK / NIDDK NIH HHS / United States
G0700222 / MRC_ / Medical Research Council / United Kingdom
064890 / WT_ / Wellcome Trust / United Kingdom
U01 DK062370 / DK / NIDDK NIH HHS / United States
DK062370 / DK / NIDDK NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
K08 AR055688 / AR / NIAMS NIH HHS / United States
U54 DA021519 / DA / NIDA NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
DK073490 / DK / NIDDK NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
U01 HG004399 / HG / NHGRI NIH HHS / United States
K23 DK065978 / DK / NIDDK NIH HHS / United States
R01 DK069922 / DK / NIDDK NIH HHS / United States
081682 / WT_ / Wellcome Trust / United Kingdom