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Association between physical activity and retinal microvascular signs: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleAssociation between physical activity and retinal microvascular signs: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2010
AuthorsTikellis G, Anuradha S, Klein R, Wong T Y
JournalMicrocirculation
Volume17
Issue5
Pagination381-93
Date Published2010 Jul
ISSN1549-8719
KeywordsAged, Analysis of Variance, Atherosclerosis, Cross-Sectional Studies, Diabetic Retinopathy, Female, Fluorescein Angiography, Humans, Leisure Activities, Male, Middle Aged, Motor Activity, Retinal Vessels, Risk Factors, Sports, Surveys and Questionnaires, United States, Work
Abstract

OBJECTIVE: To examine the association between physical activity measured during leisure, sport, and work and retinal microvascular signs.

METHODS: Participants of the Atherosclerosis Risk in Communities (ARIC) Study, a population-based cross-sectional study, had retinal photographs taken at their third follow up visit (1993-1995). Retinal microvascular signs were assessed using a standardized protocol and retinal vascular caliber by a computer-assisted method. Leisure, sport, and work-related physical activity levels were determined through a modified Baecke physical activity questionnaire.

RESULTS: A higher level of physical activity during sport and work was significantly associated with a lower prevalence of arteriovenous (AV) nicking, wider venular caliber, and retinopathy. In multivariate models, persons with a level of sport-related physical activity above the median were less likely to have AV nicking (odds ratio [OR] = 0.87; 95% confidence interval [CI] 0.78-0.97) and wider retinal venules (OR = 0.91; 95% CI: 0.83-0.99). Persons with a level of work-related physical activity above the median were less likely to have diabetic retinopathy (OR = 0.66, 95% CI: 0.51-0.85).

CONCLUSIONS: In this cross-sectional analyzes, higher levels of physical activity was associated with a lower prevalence of retinal microvascular abnormalities.

DOI10.1111/j.1549-8719.2010.00033.x
Alternate JournalMicrocirculation
PubMed ID20618695
PubMed Central IDPMC3005356
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
R01 HL069979-04 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
R01 HL069979-02 / HL / NHLBI NIH HHS / United States
R01 HL069979 / HL / NHLBI NIH HHS / United States
R01 HL069979-02S1 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01-HC-35126 / HC / NHLBI NIH HHS / United States
R01 HL069979-03 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R21 HL077166-02 / HL / NHLBI NIH HHS / United States
N01-HC-35125 / HC / NHLBI NIH HHS / United States