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Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injury.

TitleAlbuminuria and estimated glomerular filtration rate independently associate with acute kidney injury.
Publication TypeJournal Article
Year of Publication2010
AuthorsGrams ME, Astor BC, Bash LD, Matsushita K, Wang Y, Coresh J
JournalJ Am Soc Nephrol
Volume21
Issue10
Pagination1757-64
Date Published2010 Oct
ISSN1533-3450
KeywordsAcute Kidney Injury, Age Factors, Albuminuria, Cardiovascular Diseases, Comorbidity, Creatinine, Female, Glomerular Filtration Rate, Hospitalization, Humans, Incidence, Male, Middle Aged, Prospective Studies, Renal Insufficiency, Chronic, Risk Factors, Sensitivity and Specificity, United States
Abstract

Acute kidney injury (AKI) is increasingly common and a significant contributor to excess death in hospitalized patients. CKD is an established risk factor for AKI; however, the independent graded association of urine albumin excretion with AKI is unknown. We analyzed a prospective cohort of 11,200 participants in the Atherosclerosis Risk in Communities (ARIC) study for the association between baseline urine albumin-to-creatinine ratio and estimated GFR (eGFR) with hospitalizations or death with AKI. The incidence of AKI events was 4.0 per 1000 person-years of follow-up. Using participants with urine albumin-to-creatinine ratios

DOI10.1681/ASN.2010010128
Alternate JournalJ Am Soc Nephrol
PubMed ID20671214
PubMed Central IDPMC3013549
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
T32 DK007732 / DK / NIDDK NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States