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Biological, clinical and population relevance of 95 loci for blood lipids.

TitleBiological, clinical and population relevance of 95 loci for blood lipids.
Publication TypeJournal Article
Year of Publication2010
AuthorsTeslovich TM, Musunuru K, Smith AV, et al.
JournalNature
Volume466
Issue7307
Pagination707-13
Date Published2010 Aug 05
ISSN1476-4687
KeywordsAfrican Americans, Animals, Asian Continental Ancestry Group, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Europe, European Continental Ancestry Group, Female, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Lipid Metabolism, Lipids, Liver, Male, Mice, N-Acetylgalactosaminyltransferases, Phenotype, Polymorphism, Single Nucleotide, Protein Phosphatase 1, Reproducibility of Results, Triglycerides
Abstract

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P

DOI10.1038/nature09270
Alternate JournalNature
PubMed ID20686565
PubMed Central IDPMC3039276
Grant ListU01 HL080295 / HL / NHLBI NIH HHS / United States
G0701863 / MRC_ / Medical Research Council / United Kingdom
5R01HL087679-02 / HL / NHLBI NIH HHS / United States
MC_U106188470 / MRC_ / Medical Research Council / United Kingdom
RC1 HL099634-02 / HL / NHLBI NIH HHS / United States
M01-RR00425 / RR / NCRR NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
079895 / WT_ / Wellcome Trust / United Kingdom
DK078150 / DK / NIDDK NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
CZB/4/710 / CSO_ / Chief Scientist Office / United Kingdom
R01 HL087676 / HL / NHLBI NIH HHS / United States
K99HL094535 / HL / NHLBI NIH HHS / United States
G0801056 / MRC_ / Medical Research Council / United Kingdom
G9521010 / MRC_ / Medical Research Council / United Kingdom
N01-HC-85085 / HC / NHLBI NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
R01 HL089309 / HL / NHLBI NIH HHS / United States
RC1 HL099793 / HL / NHLBI NIH HHS / United States
T32 HG00040 / HG / NHGRI NIH HHS / United States
RC2 HL102419 / HL / NHLBI NIH HHS / United States
SP/08/005/25115 / BHF_ / British Heart Foundation / United Kingdom
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States
U54 RR020278 / RR / NCRR NIH HHS / United States
068545/Z/02 / WT_ / Wellcome Trust / United Kingdom
MC_U127561128 / MRC_ / Medical Research Council / United Kingdom
G0700931 / MRC_ / Medical Research Council / United Kingdom
N01-HC-55016 / HC / NHLBI NIH HHS / United States
1Z01 HG000024 / HG / NHGRI NIH HHS / United States
HL 080467 / HL / NHLBI NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
PG/02/128 / BHF_ / British Heart Foundation / United Kingdom
T32 HG000040 / HG / NHGRI NIH HHS / United States
T32 GM007092 / GM / NIGMS NIH HHS / United States
RC2 HL101864, / HL / NHLBI NIH HHS / United States
RC1 HL099634 / HL / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
ES10126 / ES / NIEHS NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
G0601966 / MRC_ / Medical Research Council / United Kingdom
TW05596 / TW / FIC NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
CA 047988 / CA / NCI NIH HHS / United States
HL-54776 / HL / NHLBI NIH HHS / United States
DK56350 / DK / NIDDK NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
RR20649 / RR / NCRR NIH HHS / United States
DK072193 / DK / NIDDK NIH HHS / United States
MC_U106179471 / MRC_ / Medical Research Council / United Kingdom
N01-HC-35129 / HC / NHLBI NIH HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
HL085144 / HL / NHLBI NIH HHS / United States
G9521010D / MRC_ / Medical Research Council / United Kingdom
R01HL087641 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
G0401527 / MRC_ / Medical Research Council / United Kingdom
N01-HC-85083 / HC / NHLBI NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
077016/Z/05/Z / WT_ / Wellcome Trust / United Kingdom
N01 HC-15103 / HC / NHLBI NIH HHS / United States
U01 HL069757 / HL / NHLBI NIH HHS / United States
RG/07/005/23633 / BHF_ / British Heart Foundation / United Kingdom
/ ImNIH / Intramural NIH HHS / United States
5R01HL08821502 / HL / NHLBI NIH HHS / United States
R01 HL089650 / HL / NHLBI NIH HHS / United States
K99 HL098364 / HL / NHLBI NIH HHS / United States
DK062370 / DK / NIDDK NIH HHS / United States
G0000934 / MRC_ / Medical Research Council / United Kingdom
R01HL087652 / HL / NHLBI NIH HHS / United States
N01-AG-12100 / AG / NIA NIH HHS / United States
PG/08/094/26019 / BHF_ / British Heart Foundation / United Kingdom
5R01HL08770003 / HL / NHLBI NIH HHS / United States
T32HL007208 / HL / NHLBI NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
N01-HC-45133 / HC / NHLBI NIH HHS / United States
K99 HL098364-01 / HL / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
MC_QA137934 / MRC_ / Medical Research Council / United Kingdom
G0801566 / MRC_ / Medical Research Council / United Kingdom
PG/08/094 / BHF_ / British Heart Foundation / United Kingdom
R24 HD050924 / HD / NICHD NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
HL 04381 / HL / NHLBI NIH HHS / United States
5R01DK07568102 / DK / NIDDK NIH HHS / United States
R01 DK078150 / DK / NIDDK NIH HHS / United States
N01-HC-85084 / HC / NHLBI NIH HHS / United States
076113/B/04/Z / WT_ / Wellcome Trust / United Kingdom
U01 DK062418 / DK / NIDDK NIH HHS / United States
5R01DK06833603 / DK / NIDDK NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States
N01-HG-65403 / HG / NHGRI NIH HHS / United States