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Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.

TitleInteractions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
Publication TypeJournal Article
Year of Publication2010
AuthorsNettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert M-F, Ngwa J, van Rooij FJA, Sonestedt E, Wojczynski MK, Ye Z, Tanaka T, Garcia M, Anderson JS, Follis JL, Djoussé L, Mukamal K, Papoutsakis C, Mozaffarian D, Zillikens CM, Bandinelli S, Bennett AJ, Borecki IB, Feitosa MF, Ferrucci L, Forouhi NG, Groves CJ, Hallmans G, Harris T, Hofman A, Houston DK, Hu FB, Johansson I, Kritchevsky SB, Langenberg C, Launer L, Liu Y, Loos RJ, Nalls M, Orho-Melander M, Renstrom F, Rice K, Riserus U, Rolandsson O, Rotter JI, Saylor G, Sijbrands EJG, Sjogren P, Smith A, Steingrímsdóttir L, Uitterlinden AG, Wareham NJ, Prokopenko I, Pankow JS, van Duijn CM, Florez JC, Witteman JCM, Dupuis J, Dedoussis GV, Ordovas JM, Ingelsson E, L Cupples A, Siscovick DS, Franks PW, Meigs JB
Corporate AuthorsMAGIC Investigators
JournalDiabetes Care
Volume33
Issue12
Pagination2684-91
Date Published2010 Dec
ISSN1935-5548
KeywordsAdult, Aged, Blood Glucose, Edible Grain, European Continental Ancestry Group, Fasting, Female, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Insulin, Male, Middle Aged, Polymorphism, Single Nucleotide
Abstract

OBJECTIVE: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin.

RESEARCH DESIGN AND METHODS: Via meta-analysis of data from 14 cohorts comprising ∼ 48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value

RESULTS: Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P

CONCLUSIONS: Our results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.

DOI10.2337/dc10-1150
Alternate JournalDiabetes Care
PubMed ID20693352
PubMed Central IDPMC2992213
Grant ListMC_UP_A620_1015 / / Medical Research Council / United Kingdom
MC_UP_A100_1003 / / Medical Research Council / United Kingdom
G19/35 / / Medical Research Council / United Kingdom
G0100222 / / Medical Research Council / United Kingdom
MC_U127561128 / / Medical Research Council / United Kingdom
G8802774 / / Medical Research Council / United Kingdom
G0902037 / / Medical Research Council / United Kingdom
R01 AG032098 / AG / NIA NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
G0701863 / / Medical Research Council / United Kingdom
MC_U106188470 / / Medical Research Council / United Kingdom
R01 HL087700 / HL / NHLBI NIH HHS / United States
RG/07/008/23674 / / British Heart Foundation / United Kingdom