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Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.

TitleAssociation of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.
Publication TypeJournal Article
Year of Publication2010
AuthorsCrawford SO, Hoogeveen RC, Brancati FL, Astor BC, Ballantyne CM, Schmidt M I, Young J H
JournalInt J Epidemiol
Volume39
Issue6
Pagination1647-55
Date Published2010 Dec
ISSN1464-3685
KeywordsAged, Aged, 80 and over, Atherosclerosis, Body Mass Index, Carotid Arteries, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Glycolysis, Humans, Insulin Resistance, Lactic Acid, Logistic Models, Magnetic Resonance Imaging, Male, Middle Aged, Obesity, Oxidative Phosphorylation, Radiography, Risk Factors, United States
Abstract

BACKGROUND: Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies.

METHODS: To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.

RESULTS: The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend

CONCLUSIONS: Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.
DOI10.1093/ije/dyq126
Alternate JournalInt J Epidemiol
PubMed ID20797988
PubMed Central IDPMC2992628
Grant ListN01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States