|Title||Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Crawford SO, Hoogeveen RC, Brancati FL, Astor BC, Ballantyne CM, Schmidt M I, Young J H|
|Journal||Int J Epidemiol|
|Date Published||2010 Dec|
|Keywords||Aged, Aged, 80 and over, Atherosclerosis, Body Mass Index, Carotid Arteries, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Glycolysis, Humans, Insulin Resistance, Lactic Acid, Logistic Models, Magnetic Resonance Imaging, Male, Middle Aged, Obesity, Oxidative Phosphorylation, Radiography, Risk Factors, United States|
BACKGROUND: Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies.
METHODS: To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
RESULTS: The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend
CONCLUSIONS: Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.
|Alternate Journal||Int J Epidemiol|
|PubMed Central ID||PMC2992628|
|Grant List||N01-HC-55022 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States