| Title | Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Kucharska-Newton AM, Monda KL, Bielinski SJ, Boerwinkle E, Rea TD, Rosamond WD, Pankow JS, Köttgen A, Heiss G, North KE |
| Journal | J Obes |
| Volume | 2010 |
| Date Published | 2010 |
| ISSN | 2090-0716 |
| Abstract | We examined the association of variation in the type 2 diabetes risk-conferring TCF7L2 gene with the risk of incident coronary heart disease (CHD) among the lean, overweight, and obese members of the Atherosclerosis Risk in Communities (ARIC) Study cohort. Cox proportional hazard regression analyses were performed using a general model, with the major homozygote as the reference category. For 9,865 whites, a significant increase in the risk of CHD was seen only among lean ( BMI |
| DOI | 10.1155/2010/651903 |
| Alternate Journal | J Obes |
| PubMed ID | 20798759 |
| PubMed Central ID | PMC2925094 |
| Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States P30 ES010126 / ES / NIEHS NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States |