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Evaluation of a novel isotope biomarker for dietary consumption of sweets.

TitleEvaluation of a novel isotope biomarker for dietary consumption of sweets.
Publication TypeJournal Article
Year of Publication2010
AuthorsYeung EH, Saudek CD, Jahren HA, Kao W H L, Islas M, Kraft R, Coresh J, Anderson CAM
JournalAm J Epidemiol
Volume172
Issue9
Pagination1045-52
Date Published2010 Nov 01
ISSN1476-6256
KeywordsAged, Aged, 80 and over, Algorithms, Atherosclerosis, Beverages, Biomarkers, Body Mass Index, Body Weight, Carbon Isotopes, Cross-Sectional Studies, Diet Surveys, Dietary Sucrose, District of Columbia, Energy Intake, Female, Food Analysis, Food Preferences, Humans, Male, Maryland, Middle Aged, Nutrition Assessment, Obesity, Surveys and Questionnaires, Sweetening Agents, Waist Circumference, Waist-Hip Ratio
Abstract

Carbon isotopic signatures ("δ¹³C") might reflect consumption of corn- and cane-based sweeteners. The authors hypothesized that the δ¹³C value of human serum is higher for individuals with high versus low intakes of corn- and cane-based sweeteners (measured as sweetened beverage intake). They conducted a cross-sectional study within the Atherosclerosis Risk in Communities Magnetic Resonance Imaging study (Maryland, 2005-2006). Diet was assessed by food frequency questionnaire, and blinded serum samples were assayed by natural abundance stable isotope mass spectroscopy. Studied were 186 participants (53% male; mean age, 71 years; mean body mass index, 30 kg/m²). Serum δ¹³C values for individuals with high sweetened beverage intakes were significantly higher than for those with low intakes (-19.15‰ vs. -19.47‰, P

DOI10.1093/aje/kwq247
Alternate JournalAm J Epidemiol
PubMed ID20817784
PubMed Central IDPMC2984252
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
K01 DK067207 / DK / NIDDK NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
DK-67207 / DK / NIDDK NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
T32 DK062707 / DK / NIDDK NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
DK-62707 / DK / NIDDK NIH HHS / United States