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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

TitleAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Publication TypeJournal Article
Year of Publication2010
AuthorsSpeliotes EK, Willer CJ, Berndt SI, et al.
Corporate AuthorsMAGIC, Procardis Consortium
JournalNat Genet
Volume42
Issue11
Pagination937-48
Date Published2010 Nov
ISSN1546-1718
KeywordsBody Height, Body Mass Index, Body Size, Body Weight, Chromosome Mapping, European Continental Ancestry Group, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Obesity, Polymorphism, Single Nucleotide
Abstract

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P

DOI10.1038/ng.686
Alternate JournalNat Genet
PubMed ID20935630
PubMed Central IDPMC3014648
Grant ListR01 MH059566 / MH / NIMH NIH HHS / United States
N01HC55020 / HL / NHLBI NIH HHS / United States
M01-RR00425 / RR / NCRR NIH HHS / United States
R01 MH061675 / MH / NIMH NIH HHS / United States
R01 CA050385 / CA / NCI NIH HHS / United States
079895 / WT_ / Wellcome Trust / United Kingdom
U01-HG004402 / HG / NHGRI NIH HHS / United States
R01-MH67257 / MH / NIMH NIH HHS / United States
CZB/4/710 / CSO_ / Chief Scientist Office / United Kingdom
G9521010 / MRC_ / Medical Research Council / United Kingdom
R01 DK073490 / DK / NIDDK NIH HHS / United States
K08 AR055688-03 / AR / NIAMS NIH HHS / United States
R01-HL088119 / HL / NHLBI NIH HHS / United States
R01-MH61675 / MH / NIMH NIH HHS / United States
K23 DK080145 / DK / NIDDK NIH HHS / United States
R01 MH063706 / MH / NIMH NIH HHS / United States
G0801056 / MRC_ / Medical Research Council / United Kingdom
R01 AA007535 / AA / NIAAA NIH HHS / United States
R01 DK058845 / DK / NIDDK NIH HHS / United States
R01-MH60870 / MH / NIMH NIH HHS / United States
N01AG12100 / AG / NIA NIH HHS / United States
MH084698 / MH / NIMH NIH HHS / United States
R56 DK062370 / DK / NIDDK NIH HHS / United States
N01-HC15103 / HC / NHLBI NIH HHS / United States
R01-HL59367 / HL / NHLBI NIH HHS / United States
R01 AA014041 / AA / NIAAA NIH HHS / United States
K05 AA017688 / AA / NIAAA NIH HHS / United States
N01HG65403 / HG / NHGRI NIH HHS / United States
R01 MH084698 / MH / NIMH NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
G0600331 / MRC_ / Medical Research Council / United Kingdom
N02-HL64278 / HL / NHLBI NIH HHS / United States
P30-DK072488 / DK / NIDDK NIH HHS / United States
079557 / WT_ / Wellcome Trust / United Kingdom
R01 HL087647 / HL / NHLBI NIH HHS / United States
U01 HL084729 / HL / NHLBI NIH HHS / United States
G0600705 / MRC_ / Medical Research Council / United Kingdom
N01-HC85086 / HC / NHLBI NIH HHS / United States
R01-MH59571 / MH / NIMH NIH HHS / United States
AA13320 / AA / NIAAA NIH HHS / United States
R01-HL087676 / HL / NHLBI NIH HHS / United States
P01 CA087969 / CA / NCI NIH HHS / United States
R01 HL087679 / HL / NHLBI NIH HHS / United States
R01-MH79470 / MH / NIMH NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
N01-HC85079 / HC / NHLBI NIH HHS / United States
R01-MH59586 / MH / NIMH NIH HHS / United States
G0000934 / MRC_ / Medical Research Council / United Kingdom
R01-MH59160 / MH / NIMH NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
RL1-MH083268 / MH / NIMH NIH HHS / United States
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R01 HL087676 / HL / NHLBI NIH HHS / United States
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R01 HL059367 / HL / NHLBI NIH HHS / United States
075491 / WT_ / Wellcome Trust / United Kingdom
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083270 / WT_ / Wellcome Trust / United Kingdom
072960 / WT_ / Wellcome Trust / United Kingdom
MC_U127561128 / MRC_ / Medical Research Council / United Kingdom
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068545 / WT_ / Wellcome Trust / United Kingdom
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CA49449 / CA / NCI NIH HHS / United States
076113 / WT_ / Wellcome Trust / United Kingdom
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DK072193 / DK / NIDDK NIH HHS / United States
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263-MA-410953 / / PHS HHS / United States
P30 DK072488 / DK / NIDDK NIH HHS / United States
Z01-HG000024 / HG / NHGRI NIH HHS / United States
MC_U106179472 / MRC_ / Medical Research Council / United Kingdom
R01DK068336 / DK / NIDDK NIH HHS / United States
R01-DK073490 / DK / NIDDK NIH HHS / United States
G0401527 / MRC_ / Medical Research Council / United Kingdom
U01 MH079470 / MH / NIMH NIH HHS / United States
R01-MH59587 / MH / NIMH NIH HHS / United States
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R01 MH059587 / MH / NIMH NIH HHS / United States
G0501184 / MRC_ / Medical Research Council / United Kingdom
Z01 HG000024 / ImNIH / Intramural NIH HHS / United States
U01-HL084756 / HL / NHLBI NIH HHS / United States
N01-HC45133 / HC / NHLBI NIH HHS / United States
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G0900554 / MRC_ / Medical Research Council / United Kingdom
090532 / WT_ / Wellcome Trust / United Kingdom
R00 HL094535 / HL / NHLBI NIH HHS / United States
086596 / WT_ / Wellcome Trust / United Kingdom
R01DK075681 / DK / NIDDK NIH HHS / United States
R01-AG031890 / AG / NIA NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
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N01-HC55018 / HC / NHLBI NIH HHS / United States
UL1-RR025005 / RR / NCRR NIH HHS / United States
R01 DA012854 / DA / NIDA NIH HHS / United States
U01 DK062370-08 / DK / NIDDK NIH HHS / United States
N01-HC85081 / HC / NHLBI NIH HHS / United States
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AA014041 / AA / NIAAA NIH HHS / United States
U54-RR020278 / RR / NCRR NIH HHS / United States
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077016 / WT_ / Wellcome Trust / United Kingdom
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R01-MH79469 / MH / NIMH NIH HHS / United States
R01-HL087679 / HL / NHLBI NIH HHS / United States
N01-HC85084 / HC / NHLBI NIH HHS / United States
R01 CA049449 / CA / NCI NIH HHS / United States
RL1 MH083268 / MH / NIMH NIH HHS / United States
R01 MH059588 / MH / NIMH NIH HHS / United States
U01-CA098233 / CA / NCI NIH HHS / United States
N01-HC25195 / HC / NHLBI NIH HHS / United States
R01-MH81800 / MH / NIMH NIH HHS / United States
U01 CA049449 / CA / NCI NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
N01-HC55016 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
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K08 AR055688 / AR / NIAMS NIH HHS / United States
085301 / WT_ / Wellcome Trust / United Kingdom
MC_U106188470 / MRC_ / Medical Research Council / United Kingdom
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G0601261 / MRC_ / Medical Research Council / United Kingdom
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U01 HG004399 / HG / NHGRI NIH HHS / United States
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N01 HC035129 / HC / NHLBI NIH HHS / United States
U01-HL72515 / HL / NHLBI NIH HHS / United States
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U54 RR020278 / RR / NCRR NIH HHS / United States
081682 / WT_ / Wellcome Trust / United Kingdom
AA13326 / AA / NIAAA NIH HHS / United States
/ CRUK_ / Cancer Research UK / United Kingdom
K23-DK080145 / DK / NIDDK NIH HHS / United States
DK46200 / DK / NIDDK NIH HHS / United States
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CA65725 / CA / NCI NIH HHS / United States
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N01-AG12100 / AG / NIA NIH HHS / United States
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