Pulse lineResearch With Heart Logo

Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes.

TitleGlycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes.
Publication TypeJournal Article
Year of Publication2011
AuthorsSelvin E, Ning Y, Steffes MW, Bash LD, Klein R, Wong TY, Astor BC, A Sharrett R, Brancati FL, Coresh J
JournalDiabetes
Volume60
Issue1
Pagination298-305
Date Published2011 Jan
ISSN1939-327X
KeywordsAdult, Alcohol Drinking, Atherosclerosis, Blood Glucose, Cholesterol, HDL, Cholesterol, LDL, Continental Population Groups, Cross-Sectional Studies, Diabetic Nephropathies, Diabetic Retinopathy, Female, Glycated Hemoglobin A, Humans, Kidney Diseases, Life Style, Male, Odds Ratio, Prevalence, Prospective Studies, Retinal Diseases, Risk Factors, Smoking, Triglycerides
Abstract

OBJECTIVE: Glycated hemoglobin was recently recommended for use as a diagnostic test for diabetes. We examined the association between 2010 American Diabetes Association diagnostic cut points for glycated hemoglobin and microvascular outcomes (chronic kidney disease, end-stage renal disease [ESRD], and retinopathy) and formally tested for the presence of risk thresholds in the relationships of glycated hemoglobin with these outcomes.

RESEARCH DESIGN AND METHODS: Prospective cohort and cross-sectional analyses of 11,357 participants (773 with a history of diagnosed diabetes) from the Atherosclerosis Risk in Communities (ARIC) Study.

RESULTS: During a median of 14 years of follow-up of individuals without diagnosed diabetes at baseline, clinical categories of glycated hemoglobin were associated with risk of chronic kidney disease, with adjusted hazard ratios (HRs) of 1.12 (0.94-1.34) and 1.39 (1.04-1.85) for glycated hemoglobin 5.7-6.4% and ≥6.5%, respectively, as compared with

CONCLUSIONS: These data from a community-based, biracial population support the use of new 2010 American Diabetes Association glycated hemoglobin cut points for the diagnosis of diabetes.

DOI10.2337/db10-1198
Alternate JournalDiabetes
PubMed ID20978092
PubMed Central IDPMC3012185
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
R21 DK-080294 / DK / NIDDK NIH HHS / United States
P60 DK-079637 / DK / NIDDK NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
T32 HL-007024 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
K01 DK-076595 / DK / NIDDK NIH HHS / United States
P60 DK079637 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R01 DK076770 / DK / NIDDK NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
K24 DK-62222 / DK / NIDDK NIH HHS / United States
R21 DK080294 / DK / NIDDK NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
K24 DK062222 / DK / NIDDK NIH HHS / United States
R01 DK-076770 / DK / NIDDK NIH HHS / United States