Title | Reliability and sensitivity of the self-report of physician-diagnosed gout in the campaign against cancer and heart disease and the atherosclerosis risk in the community cohorts. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | McAdams MA, Maynard JW, Baer AN, Köttgen A, Clipp S, Coresh J, Gelber AC |
Journal | J Rheumatol |
Volume | 38 |
Issue | 1 |
Pagination | 135-41 |
Date Published | 2011 Jan |
ISSN | 0315-162X |
Keywords | Atherosclerosis, Cohort Studies, Epidemiologic Studies, Female, Gout, Heart Diseases, Humans, Male, Neoplasms, Physicians, Reproducibility of Results, Residence Characteristics, Risk Factors, Self Report, Sensitivity and Specificity, Surveys and Questionnaires |
Abstract | OBJECTIVE: gout is often defined by self-report in epidemiologic studies. Yet the validity of self-reported gout is uncertain. We evaluated the reliability and sensitivity of the self-report of physician-diagnosed gout in the Campaign Against Cancer and Heart Disease (CLUE II) and the Atherosclerosis Risk in the Community (ARIC) cohorts. METHODS: the CLUE II cohort comprises 12,912 individuals who self-reported gout status on either the 2000, 2003, or 2007 questionnaires. We calculated reliability as the percentage of participants reporting having gout on more than 1 questionnaire using Cohen's κ statistic. The ARIC cohort comprises 11,506 individuals who self-reported gout status at visit 4. We considered a hospital discharge diagnosis of gout or use of a gout-specific medication as the standard against which to calculate the sensitivity of self-reported, physician-diagnosed gout. RESULTS: of the 437 CLUE II participants who self-reported physician-diagnosed gout in 2000, and subsequently answered the 2003 questionnaire, 75% reported gout in 2003 (κ = 0.73). Of the 271 participants who reported gout in 2000, 73% again reported gout at the 2007 followup questionnaire (κ = 0.63). In ARIC, 196 participants met the definition for gout prior to visit 4 and self-reported their gout status at visit 4. The sensitivity of a self-report of physician-diagnosed gout was 84%. Accuracy was similar across sex and race subgroups, but differed across hyperuricemia and education strata. CONCLUSION: these 2 population-based US cohorts suggest that self-report of physician-diagnosed gout has good reliability and sensitivity. Thus, self-report of a physician diagnosis of gout is appropriate for epidemiologic studies. |
DOI | 10.3899/jrheum.100418 |
Alternate Journal | J Rheumatol |
PubMed ID | 21123328 |
PubMed Central ID | PMC3285109 |
Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States T32 HL007024-35 / HL / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States 5T32HL007024 / HL / NHLBI NIH HHS / United States N01-HC55018 / HC / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States R01 CA105069 / CA / NCI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States U01 AG018033 / AG / NIA NIH HHS / United States T32 HL007024 / HL / NHLBI NIH HHS / United States 1KL2RR025006-01 / RR / NCRR NIH HHS / United States U01 AG18033 / AG / NIA NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States KL2 RR025006 / RR / NCRR NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States |