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Carotid artery wall thickness and risk of stroke subtypes: the atherosclerosis risk in communities study.

TitleCarotid artery wall thickness and risk of stroke subtypes: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2011
AuthorsOhira T, Shahar E, Iso H, Chambless LE, Rosamond WD, A Sharrett R, Folsom AR
JournalStroke
Volume42
Issue2
Pagination397-403
Date Published2011 Feb
ISSN1524-4628
KeywordsCarotid Arteries, Carotid Artery Diseases, Cohort Studies, Endothelium, Vascular, Female, Follow-Up Studies, Humans, Male, Middle Aged, Residence Characteristics, Risk Factors, Stroke
Abstract

BACKGROUND AND PURPOSE: Understanding associations of carotid atherosclerosis with stroke subtypes may contribute to more effective prevention of stroke.

METHODS: Between 1987 and 1989, 13 560 men and women aged 45 to 64 years and free of clinical stroke took part in the first examination of the Atherosclerosis Risk in Communities (ARIC) study. Incident strokes were ascertained by hospital surveillance.

RESULTS: During an average follow-up of 15.7 years, 82 incident hemorrhagic and 621 incident ischemic strokes (131 lacunar, 358 nonlacunar, and 132 cardioembolic strokes) occurred. The incidence rates of hemorrhagic and ischemic strokes were greater across higher carotid intima-media thickness levels. Although this positive association was observed for all stroke subtypes, the age-, gender-, and race-adjusted risk ratios were higher for cardioembolic and nonlacunar strokes than for hemorrhagic and lacunar strokes. Compared with participants in the lowest quintile (

CONCLUSIONS: Carotid atherosclerosis was associated with increased risk of all stroke subtypes, but the association of carotid atherosclerosis with stroke may vary by subtypes.

DOI10.1161/STROKEAHA.110.592261
Alternate JournalStroke
PubMed ID21164133
PubMed Central IDPMC3026889
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States