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Are lung disease and function related to age-related macular degeneration?

TitleAre lung disease and function related to age-related macular degeneration?
Publication TypeJournal Article
Year of Publication2011
AuthorsMoorthy S, Cheung N, Klein R, Shahar E, Wong TY
JournalAm J Ophthalmol
Volume151
Issue2
Pagination375-9
Date Published2011 Feb
ISSN1879-1891
KeywordsAsthma, Cross-Sectional Studies, Female, Forced Expiratory Volume, Humans, Lung Diseases, Macular Degeneration, Male, Middle Aged, Photography, Spirometry, Surveys and Questionnaires
Abstract

PURPOSE: To describe the relationship of lung disease and function with early age-related macular degeneration (AMD) in a population-based study.

DESIGN: A population-based, cross-sectional study of 12,596 middle-aged participants from the Atherosclerosis Risk in Communities Study.

METHODS: Lung function was assessed by spirometry. Physician diagnosis of asthma and lung disease was ascertained from a standardized questionnaire. AMD signs were graded from fundus photographs according to the Wisconsin grading protocol.

RESULTS: Among the study population, 587 (4.7%) had early AMD, 638 (5.1%) had asthma, and 581 (4.6%) had lung disease. After adjusting for age, gender, smoking, and hypertension, each 1-L increase in predicted forced expiratory volume in 1 second (odds ratio [OR], 1.27; 95% confidence interval [CI], 0.89 to 1.80), forced vital capacity (OR, 1.18; 95% CI, 0.93 to 1.51), and peak expiratory flow rate (OR, 1.12; 95% CI, 0.95 to 1.33) were not significantly associated with early AMD. Forced expiratory volume in 1 second-to-forced vital capacity ratio (second quartile OR, 1.61; 95% CI, 0.88 to 2.93, third quartile OR, 1.65; 95% CI 0.90 to 3.03; fourth quartile OR, 1.28; 95% CI 0.68 to 2.40) was not associated significantly with early AMD. Similarly, asthma (OR, 1.06; 95% CI, 0.86 to 1.27) and other lung diseases (OR, 1.08; 95% CI, 0.90 to 1.29) were not associated with early AMD.

CONCLUSIONS: Our data do not support a cross-sectional association between lung disease and risk of early AMD.

DOI10.1016/j.ajo.2010.09.001
Alternate JournalAm J Ophthalmol
PubMed ID21168814
PubMed Central IDPMC3040408
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R21 HL077166-01 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States