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Scan-Rescan reproducibility of carotid bifurcation geometry from routine contrast-enhanced MR angiography.

TitleScan-Rescan reproducibility of carotid bifurcation geometry from routine contrast-enhanced MR angiography.
Publication TypeJournal Article
Year of Publication2011
AuthorsBijari PB, Antiga L, Wasserman BA, Steinman DA
JournalJ Magn Reson Imaging
Volume33
Issue2
Pagination482-9
Date Published2011 Feb
ISSN1522-2586
KeywordsCarotid Arteries, Carotid Artery Diseases, Contrast Media, Feasibility Studies, Gadolinium DTPA, Humans, Imaging, Three-Dimensional, Magnetic Resonance Angiography, Reproducibility of Results, Sensitivity and Specificity
Abstract

PURPOSE: To demonstrate the feasibility of rapid and reliable geometric characterization of normal carotid bifurcation geometry from routine 3D contrast-enhanced magnetic resonance (MR) angiograms.

MATERIALS AND METHODS: Repeat scans of 61 participants, acquired as part of the Atherosclerosis Risk in Communities (ARIC) Carotid MRI substudy, were digitally segmented using automated 3D level set methods, relying on an operator only to select the branch endpoints and thresholds for the 3D lumen surface initialization. Geometric factors characterizing the 3D lumen geometry were then extracted automatically.

RESULTS: Of 122 scans, 117 could be segmented within 5 minutes each, with 40% being of sufficiently high quality to require less than 2 minutes each. Irrespective of scan quality, geometric factors were found to be highly reproducible, with intraclass correlation coefficients (ICCs) typically above 0.9. The reconstructed lumen surfaces were reproducible to 0.99), with lumen surface differences

CONCLUSION: The 3D geometry of the carotid bifurcation can be characterized rapidly and with a high degree of consistency, even for suboptimal image qualities. This bodes well for large-scale retrospective or prospective studies aimed at teasing out the influence of local vs. systemic risk factors for early atherosclerosis.

DOI10.1002/jmri.22440
Alternate JournalJ Magn Reson Imaging
PubMed ID21274992
PubMed Central IDPMC3059724
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
MOP-62934 / / Canadian Institutes of Health Research / Canada
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
U01 HL075572 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
U01 HL075572-01 / HL / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
U01HL075572-01 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States