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Lower urinary connective tissue growth factor levels and incident CKD stage 3 in the general population.

TitleLower urinary connective tissue growth factor levels and incident CKD stage 3 in the general population.
Publication TypeJournal Article
Year of Publication2011
AuthorsO'Seaghdha CM, Hwang S-J, Bhavsar NA, Köttgen A, Coresh J, Astor BC, Fox CS
JournalAm J Kidney Dis
Volume57
Issue6
Pagination841-9
Date Published2011 Jun
ISSN1523-6838
KeywordsBiomarkers, Connective Tissue Growth Factor, Disease Progression, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Incidence, Kidney Failure, Chronic, Male, Middle Aged, Nephelometry and Turbidimetry, Population Surveillance, Prognosis, Prospective Studies, Severity of Illness Index, United States
Abstract

BACKGROUND: Connective tissue growth factor (CTGF) is involved in the development and progression of kidney diseases, including diabetic nephropathy and kidney fibrosis, but also may have a role in mesangial repair after injury. It is unknown whether, in the general population, urinary CTGF levels are associated with a decrease in estimated glomerular filtration rate (eGFR) to

STUDY DESIGN: Nested case-control.

SETTING & PARTICIPANTS: 100 cases of incident CKD stage 3 and 100 age-and sex-matched controls in the Framingham Heart Study; 141 cases and 135 age-, sex-, and race-matched controls in the Atherosclerosis Risk in Communities (ARIC) Study. Controls had eGFR ≥60 mL/min/1.73 m(2) at follow-up in both studies.

PREDICTORS: Urinary CTGF concentrations.

OUTCOMES: Incident CKD stage 3, defined as eGFR

MEASUREMENTS: Stored urine samples from Framingham Heart Study and ARIC were measured for CTGF. Covariates were obtained from Framingham Heart Study and ARIC participant examinations.

RESULTS: In the Framingham Heart Study, the median baseline urinary CTGF concentration was lower in cases (1.35 ng/mL) than controls (2.35 ng/mL; paired t test, P

LIMITATIONS: Observational study; causality cannot be inferred.

CONCLUSIONS: Lower urinary CTGF concentrations precede the onset of CKD stage 3 in the general population. Further work is required to fully characterize how CTGF level influences risk of CKD.

DOI10.1053/j.ajkd.2010.11.022
Alternate JournalAm J Kidney Dis
PubMed ID21292366
PubMed Central IDPMC3100386
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
N01 HC055022 / HC / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
1R01 DK076770-01 / DK / NIDDK NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
U01 HL075572 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
U01 HL075572-01 / HL / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
R01 DK076770-01 / DK / NIDDK NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R01 DK076770 / DK / NIDDK NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
U01HL075572-01 / HL / NHLBI NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States