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Nontraditional markers of glycemia: associations with microvascular conditions.

TitleNontraditional markers of glycemia: associations with microvascular conditions.
Publication TypeJournal Article
Year of Publication2011
AuthorsSelvin E, Francis LMA, Ballantyne CM, Hoogeveen RC, Coresh J, Brancati FL, Steffes MW
JournalDiabetes Care
Volume34
Issue4
Pagination960-7
Date Published2011 Apr
ISSN1935-5548
KeywordsAged, Aged, 80 and over, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Female, Fructosamine, Glycated Hemoglobin A, Humans, Male, Middle Aged, Odds Ratio, Serum Albumin
Abstract

OBJECTIVE: To compare the associations of nontraditional (fructosamine, glycated albumin, 1,5-anhydroglucitol [1,5-AG]) and standard (fasting glucose, HbA(1c)) glycemic markers with common microvascular conditions associated with diabetes mellitus.

RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study of 1,600 participants (227 with a history of diabetes and 1,323 without) from the Atherosclerosis Risk in Communities (ARIC) Study, a community-based population. We conducted logistic regression analyses of the associations of diabetes-specific tertiles of fructosamine, glycated albumin, 1/(1,5-AG), fasting glucose, and HbA(1c) with prevalence of chronic kidney disease, albuminuria, and retinopathy after adjustment for demographic, clinical, and lifestyle variables.

RESULTS: We observed significant positive trends in the associations of each marker with albuminuria and retinopathy, even after accounting for demographic, clinical, and lifestyle factors (all P trends

CONCLUSIONS: In cross-sectional analyses, two serum markers of glycemia-glycated albumin and fructosamine-are as, or more strongly, associated with microvascular conditions as HbA(1c). These markers may be useful in settings where whole blood is not available. Whether they might complement or outperform HbA(1c) in terms of long-term predictive value requires further investigation.

DOI10.2337/dc10-1945
Alternate JournalDiabetes Care
PubMed ID21335368
PubMed Central IDPMC3064058
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
K01-DK-076595 / DK / NIDDK NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
P60-DK-079637 / DK / NIDDK NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
R21-DK-080294 / DK / NIDDK NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
P60 DK079637 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
K24-DK-62222 / DK / NIDDK NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
R21 DK080294 / DK / NIDDK NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
K24 DK062222 / DK / NIDDK NIH HHS / United States