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Serum potassium and the racial disparity in diabetes risk: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleSerum potassium and the racial disparity in diabetes risk: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2011
AuthorsChatterjee R, Yeh H-C, Shafi T, Anderson C, Pankow JS, Miller ER, Levine D, Selvin E, Brancati FL
JournalAm J Clin Nutr
Volume93
Issue5
Pagination1087-91
Date Published2011 May
ISSN1938-3207
KeywordsAfrican Americans, Atherosclerosis, Body Mass Index, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Health Status Disparities, Humans, Hypokalemia, Incidence, Male, Middle Aged, Potassium, Proportional Hazards Models, Prospective Studies, Risk Factors, United States
Abstract

BACKGROUND: Low serum potassium appears to be independently associated with incident type 2 diabetes, and low dietary potassium is more common in African Americans than in whites.

OBJECTIVE: We hypothesized that low serum potassium contributes to the excess risk of diabetes in African Americans.

DESIGN: We analyzed data collected from 1987 to 1996 from the Atherosclerosis Risk in Communities (ARIC) Study. At baseline, we identified 2716 African American and 9493 white participants without diabetes. We used multivariate Cox models to estimate the relative hazards (RHs) of incident diabetes related to baseline serum potassium during 9 y of follow-up.

RESULTS: Mean serum potassium concentrations were lower in African Americans than in whites at baseline (4.2 compared with 4.5 mEq/L; P

CONCLUSIONS: Low serum potassium concentrations in African Americans may contribute to their excess risk of type 2 diabetes relative to whites. Whether interventions to increase serum potassium concentrations in African Americans might reduce their excess risk deserves further study. The ARIC Study is registered at clinicaltrials.gov as NCT00005131.

DOI10.3945/ajcn.110.007286
Alternate JournalAm J Clin Nutr
PubMed ID21367942
PubMed Central IDPMC3076658
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
K24 DK062222-01 / DK / NIDDK NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
K23 DK083514 / DK / NIDDK NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
P60 DK079637-01 / DK / NIDDK NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
R01 DK056918-03 / DK / NIDDK NIH HHS / United States
P60 DK079637 / DK / NIDDK NIH HHS / United States
T32 HL007180-23 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
T32 HL007180 / HL / NHLBI NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
K24 DK062222-10 / DK / NIDDK NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
K01 DK076595-01 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
R21 DK080294-02 / DK / NIDDK NIH HHS / United States
K24 DK62222 / DK / NIDDK NIH HHS / United States
R21 DK080294 / DK / NIDDK NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R01 DK056918 / DK / NIDDK NIH HHS / United States