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The ARIC carotid MRI study of blood cellular markers: an inverse association of monocyte myeloperoxidase content with peripheral arterial disease.

TitleThe ARIC carotid MRI study of blood cellular markers: an inverse association of monocyte myeloperoxidase content with peripheral arterial disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsMatijevic N, Wu KK, Nidkarni N, Heiss G
Secondary AuthorsFolsom AR
JournalAngiology
Volume62
Issue3
Pagination237-44
Date Published2011 Apr
ISSN1940-1574
KeywordsAfrican Americans, Aged, Biomarkers, Carotid Arteries, CD40 Ligand, Cyclooxygenase 2, European Continental Ancestry Group, Female, Flow Cytometry, Humans, Logistic Models, Magnetic Resonance Imaging, Male, Monocytes, P-Selectin, Peripheral Arterial Disease, Peroxidase, Platelet Membrane Glycoproteins, Toll-Like Receptor 2, Toll-Like Receptor 4
Abstract

We evaluated the association of blood monocyte and platelet activation markers with the risk of peripheral artery disease (PAD) in a multicenter study of atherosclerosis among African American and Caucasian patients. Flow cytometric analysis of blood cells was performed in 1791 participants (209 cases with PAD and 1582 noncases) from the cross-sectional Atherosclerosis Risk in Communities Carotid Magnetic Resonance Imaging ([MRI] ARIC Carotid MRI) Study to assess platelet glycoproteins IIb and IIIa, P-selectin, CD40 ligand, platelet-leukocyte aggregates, monocyte lipopolysaccharide receptor, toll-like receptors (TLRs) 2 and 4, P-selectin glycoprotein ligand 1, cyclooxygenase 2, and myeloperoxidase. Multivariate regression analyses evaluated the association of cellular markers with the risk of PAD. After adjusting for age, race, and gender, platelet CD40L, and monocyte myeloperoxidase (mMPO) levels were significantly lower (P

DOI10.1177/0003319710385336
Alternate JournalAngiology
PubMed ID21406422
PubMed Central IDPMC4685672
Grant ListN01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
U01 HL075572 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
U01HL075572-01 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
N01-HC55020 / HC / NHLBI NIH HHS / United States