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The MYH9/APOL1 region and chronic kidney disease in European-Americans.

TitleThe MYH9/APOL1 region and chronic kidney disease in European-Americans.
Publication TypeJournal Article
Year of Publication2011
AuthorsO'Seaghdha CM, Parekh RS, Hwang S-J, Li M, Köttgen A, Coresh J, Yang Q, Fox CS, Kao LWH
JournalHum Mol Genet
Volume20
Issue12
Pagination2450-6
Date Published2011 Jun 15
ISSN1460-2083
KeywordsCohort Studies, European Continental Ancestry Group, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Kidney Diseases, Models, Biological, Molecular Motor Proteins, Myosin Heavy Chains, Polymorphism, Single Nucleotide, United States
Abstract

Polymorphisms in the MYH9 and adjacent APOL1 gene region demonstrate a strong association with non-diabetic kidney disease in African-Americans. However, it is not known to what extent these polymorphisms are present in other ethnic groups. To examine the association of genetic polymorphisms in this region with chronic kidney disease (CKD; estimated glomerular filtration rate

DOI10.1093/hmg/ddr118
Alternate JournalHum Mol Genet
PubMed ID21429915
PubMed Central IDPMC3098737
Grant ListUL1RR025005 / RR / NCRR NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States