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Genetic variability of smoking persistence in African Americans.

TitleGenetic variability of smoking persistence in African Americans.
Publication TypeJournal Article
Year of Publication2011
AuthorsHamidovic A, Kasberger JL, Young TR, Goodloe RJ, Redline S, Buxbaum SG, Benowitz NL, Bergen AW, Butler KR, Franceschini N, Gharib SA, Hitsman B, Levy D, Meng Y, Papanicolaou GJ, Preis SR, Spring B, Styn MA, Tong EK, White WB, Wiggins KL, Jorgenson E
JournalCancer Prev Res (Phila)
Volume4
Issue5
Pagination729-34
Date Published2011 May
ISSN1940-6215
KeywordsAfrican Americans, Aged, Atherosclerosis, Brain-Derived Neurotrophic Factor, Chromosomes, Human, Pair 15, Cohort Studies, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Neoplasm Staging, Nerve Tissue Proteins, Phenotype, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Prognosis, Receptors, Nicotinic, Risk Factors, Smoking
Abstract

To date, most genetic association analyses of smoking behaviors have been conducted in populations of European ancestry and many of these studies focused on the phenotype that measures smoking quantity, that is, cigarettes per day. Additional association studies in diverse populations with different linkage disequilibrium patterns and an alternate phenotype, such as total tobacco exposure which accounts for intermittent periods of smoking cessation within a larger smoking period as measured in large cardiovascular risk studies, can aid the search for variants relevant to smoking behavior. For these reasons, we undertook an association analysis by using a genotyping array that includes 2,100 genes to analyze smoking persistence in unrelated African American participants from the Atherosclerosis Risk in Communities study. A locus located approximately 4 kb downstream from the 3'-UTR of the brain-derived neurotrophic factor (BDNF) significantly influenced smoking persistence. In addition, independent variants rs12915366 and rs12914385 in the cluster of genes encoding nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4) on 15q25.1 were also associated with the phenotype in this sample of African American subjects. To our knowledge, this is the first study to more extensively evaluate the genome in the African American population, as a limited number of previous studies of smoking behavior in this population included evaluations of only single genomic regions.

DOI10.1158/1940-6207.CAPR-10-0362
Alternate JournalCancer Prev Res (Phila)
PubMed ID21436384
PubMed Central IDPMC3095514
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
F32 DA024920 / DA / NIDA NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
KL2 RR024130 / RR / NCRR NIH HHS / United States
UL1 RR025741 / RR / NCRR NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
U54 CA153499 / CA / NCI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
F32DA024920 / DA / NIDA NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
F32 DA024920-02 / DA / NIDA NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
KL2 RR024130-02 / RR / NCRR NIH HHS / United States