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P wave indices, obesity, and the metabolic syndrome: the atherosclerosis risk in communities study.

TitleP wave indices, obesity, and the metabolic syndrome: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2012
AuthorsMagnani JW, Lopez FL, Soliman EZ, Maclehose RF, Crow RS, Alonso A
JournalObesity (Silver Spring)
Volume20
Issue3
Pagination666-72
Date Published2012 Mar
ISSN1930-739X
KeywordsAtherosclerosis, Atrial Fibrillation, Cohort Studies, Cross-Sectional Studies, Electrocardiography, Female, Heart Conduction System, Humans, Male, Metabolic Syndrome, Middle Aged, Multivariate Analysis, Obesity, Risk Factors, Surveys and Questionnaires, United States
Abstract

Atrial fibrillation and obesity are increasing in prevalence and are interrelated epidemics. There has been limited assessment of how obesity and the metabolic syndrome impact P wave indices, established electrocardiographic predictors of atrial fibrillation. We conducted a cross-sectional analysis to determine the association of obesity and the components of the metabolic syndrome with P wave indices in the population-based Atherosclerosis Risk in Communities (ARIC) study. Analyses were adjusted for demographic, anthropometric and clinical variables, and cardiovascular diseases and risk factors. Following relevant exclusions, 14,433 subjects were included (55% women and 24.7% black). In multivariable analyses, we identified significant, progressive increases in PR interval, P wave maximum duration, and P wave terminal force with BMI 25-30 kg/m(2) and BMI ≥30 kg/m(2) compared to the reference group

DOI10.1038/oby.2011.53
Alternate JournalObesity (Silver Spring)
PubMed ID21475136
PubMed Central IDPMC3696958
Grant ListN01-HC -55015 / HC / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC -55016 / HC / NHLBI NIH HHS / United States
RC1 HL099452 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC -55020 / HC / NHLBI NIH HHS / United States
L30 HL097675 / HL / NHLBI NIH HHS / United States
N01-HC -55019 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01-HC -55021 / HC / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC -55018 / HC / NHLBI NIH HHS / United States
N01-HC -55022 / HC / NHLBI NIH HHS / United States
R21 HL106092 / HL / NHLBI NIH HHS / United States