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Association of blood monocyte and platelet markers with carotid artery characteristics: the atherosclerosis risk in communities carotid MRI study.

TitleAssociation of blood monocyte and platelet markers with carotid artery characteristics: the atherosclerosis risk in communities carotid MRI study.
Publication TypeJournal Article
Year of Publication2011
AuthorsMatijevic N, Wu KK, Howard AG, Wasserman B, Wang WY-W, Folsom AR, Sharrett AR
JournalCerebrovasc Dis
Volume31
Issue6
Pagination552-8
Date Published2011
ISSN1421-9786
KeywordsAged, Biomarkers, Blood Platelets, Carotid Arteries, Carotid Artery Diseases, Cross-Sectional Studies, Female, Flow Cytometry, Humans, Immunophenotyping, Magnetic Resonance Imaging, Male, Middle Aged, Monocytes, Prevalence, Prospective Studies, Residence Characteristics, Risk Factors
Abstract

BACKGROUND: Atherosclerosis is characterized by infiltration of inflammatory cells from circulating blood. Blood cell activation could play an important role in plaque formation.

METHODS: We analyzed the relationship between blood cellular markers and quantitative measures of carotid wall components in 1,546 participants from the ARIC (Atherosclerosis Risk in Communities) Carotid MRI Study. Carotid imaging was performed using a gadolinium contrast-enhanced MRI and cellular phenotyping by flow cytometry.

RESULTS: Monocyte Toll-like receptor (TLR)-2 is associated with larger plaques, while CD14, myeloperoxidase, and TLR-4 associate with smaller. Platelet CD40L is associated with smaller plaques and thinner caps, while P-selectin is associated with smaller core size.

CONCLUSIONS: Blood cell activation is significantly associated with atherosclerotic changes of the carotid wall.

DOI10.1159/000324389
Alternate JournalCerebrovasc Dis
PubMed ID21487219
PubMed Central IDPMC3085521
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
U01 HL075572 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
U01HL075572-01 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States