Title | Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi M T, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE |
Journal | PLoS Genet |
Volume | 7 |
Issue | 4 |
Pagination | e1002033 |
Date Published | 2011 Apr |
ISSN | 1553-7404 |
Keywords | Adult, Aged, Caffeine, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 7, Cytochrome P-450 CYP1A2, Drinking Behavior, Female, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Quality Control, Receptors, Aryl Hydrocarbon, Sex Factors, United States, Whites |
Abstract | We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2. |
DOI | 10.1371/journal.pgen.1002033 |
Alternate Journal | PLoS Genet |
PubMed ID | 21490707 |
PubMed Central ID | PMC3071630 |
Grant List | R01HL59367 / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States Z01 CP010200 / ImNIH / Intramural NIH HHS / United States U01 HG004729 / HG / NHGRI NIH HHS / United States R01 CA063464 / CA / NCI NIH HHS / United States U01 HG004735 / HG / NHGRI NIH HHS / United States U01 CA136792 / CA / NCI NIH HHS / United States CA136792 / CA / NCI NIH HHS / United States N01HC55020 / HL / NHLBI NIH HHS / United States U01HG004446 / HG / NHGRI NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States CA54281 / CA / NCI NIH HHS / United States P01CA089392 / CA / NCI NIH HHS / United States U01HG004726 / HG / NHGRI NIH HHS / United States U01HG004438 / HG / NHGRI NIH HHS / United States R01 DK058845 / DK / NIDDK NIH HHS / United States U01 HG004728 / HG / NHGRI NIH HHS / United States U01 HG004438 / HG / NHGRI NIH HHS / United States U10AA008401 / AA / NIAAA NIH HHS / United States P01CA087969 / CA / NCI NIH HHS / United States U01 HG004446 / HG / NHGRI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States AHG006033 / / PHS HHS / United States U01HG004738 / HG / NHGRI NIH HHS / United States P01 CA087969 / CA / NCI NIH HHS / United States HL 043851 / HL / NHLBI NIH HHS / United States P01CA055075 / CA / NCI NIH HHS / United States U01-CA98233 / CA / NCI NIH HHS / United States HL69757 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States U01HG004415 / HG / NHGRI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States R01 HL043851 / HL / NHLBI NIH HHS / United States U01 DE018993 / DE / NIDCR NIH HHS / United States P01 CA055075 / CA / NCI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States P01 DK070756 / DK / NIDDK NIH HHS / United States P01 CA089392 / CA / NCI NIH HHS / United States / CAPMC / CIHR / Canada U01HG004728 / HG / NHGRI NIH HHS / United States U01HG004399 / HG / NHGRI NIH HHS / United States 5P01DK070756 / DK / NIDDK NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States CA55075 / CA / NCI NIH HHS / United States U01 HG004424 / HG / NHGRI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States 01HG004735 / HG / NHGRI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States U01 HG004415 / HG / NHGRI NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States U01HG004422 / HG / NHGRI NIH HHS / United States CA 047988 / CA / NCI NIH HHS / United States CA63464 / CA / NCI NIH HHS / United States HHSN268200782096C / HG / NHGRI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States U01 HG004422 / HG / NHGRI NIH HHS / United States U01HG04424 / HG / NHGRI NIH HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States R01 DA013423 / DA / NIDA NIH HHS / United States U01DE018993 / DE / NIDCR NIH HHS / United States U01HG004423 / HG / NHGRI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States HL35464 / HL / NHLBI NIH HHS / United States R01 CA054281 / CA / NCI NIH HHS / United States U01 CA098233 / CA / NCI NIH HHS / United States R01DK058845 / DK / NIDDK NIH HHS / United States U01DE018903 / DE / NIDCR NIH HHS / United States U01 CA063464 / CA / NCI NIH HHS / United States R01 CA047988 / CA / NCI NIH HHS / United States U01HG004436 / HG / NHGRI NIH HHS / United States U01HG004729 / HG / NHGRI NIH HHS / United States 01DA013423 / DA / NIDA NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States U01 DE018903 / DE / NIDCR NIH HHS / United States U01 HG004436 / HG / NHGRI NIH HHS / United States U19 HL069757 / HL / NHLBI NIH HHS / United States R01 HL035464 / HL / NHLBI NIH HHS / United States U01 HG004738 / HG / NHGRI NIH HHS / United States U10 AA008401 / AA / NIAAA NIH HHS / United States U01 HG004423 / HG / NHGRI NIH HHS / United States R01 CA040356 / CA / NCI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States U01 HL069757 / HL / NHLBI NIH HHS / United States R37 CA054281 / CA / NCI NIH HHS / United States U01 HG004399 / HG / NHGRI NIH HHS / United States R01HL086694 / HL / NHLBI NIH HHS / United States CA 40356 / CA / NCI NIH HHS / United States U01 HG004726 / HG / NHGRI NIH HHS / United States |