Title | Serum 25-hydroxyvitamin D, calcium, phosphorus, and electrocardiographic QT interval duration: findings from NHANES III and ARIC. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Zhang Y, Post WS, Dalal D, Bansal S, Blasco-Colmenares E, Jan De Beur S, Alonso A, Soliman EZ, Whitsel EA, Brugada R, Tomaselli GF, Guallar E |
Journal | J Clin Endocrinol Metab |
Volume | 96 |
Issue | 6 |
Pagination | 1873-82 |
Date Published | 2011 Jun |
ISSN | 1945-7197 |
Keywords | Calcium, Cross-Sectional Studies, Electrocardiography, Female, Heart Conduction System, Humans, Male, Middle Aged, Phosphorus, Vitamin D |
Abstract | CONTEXT: Disturbances in 25-hydroxyvitamin D, calcium, and phosphorus concentrations have been associated with increased risks of total and cardiovascular mortality. It is possible that changes in electrocardiographic QT interval duration may mediate these effects, but the association of 25-hydroxyvitamin D, phosphorus, and calcium concentrations with QT interval duration has not been evaluated in general population samples. OBJECTIVE: The objective of the study was to evaluate the association of 25-hydroxyvitamin D, phosphorus, and calcium concentrations with QT interval duration in two large samples of the U.S. general population. DESIGN: This study included cross-sectional analyses the Third National Health and Nutrition Survey (NHANES III) and the Atherosclerosis Risk in Communities (ARIC) study. SETTING: The study was conducted in the general community. PATIENTS OR OTHER PARTICIPANTS: Patients included 7,312 men and women from NHANES III and 14,825 men and women from the ARIC study. INTERVENTIONS: Serum 25-hydroxyvitamin D, total and ionized calcium, and inorganic phosphorus were measured in NHANES III, and serum total calcium and inorganic phosphorus were measured in ARIC. MAIN OUTCOME MEASURE: QT interval duration was obtained from standard 12-lead electrocardiograms. RESULTS: In NHANES III, the multivariate adjusted differences in average QT interval duration comparing the highest vs. the lowest quartiles of serum total calcium, ionized calcium, and phosphorus were -3.6 msec (-5.8 to -1.3; P for trend = 0.005), -5.4 msec (-7.4 to -3.5; P for trend CONCLUSIONS: In two large samples of the general population, QT interval duration was inversely associated with the serum total and ionized calcium and positively associated with serum phosphorus. |
DOI | 10.1210/jc.2010-2969 |
Alternate Journal | J Clin Endocrinol Metab |
PubMed ID | 21508137 |
PubMed Central ID | PMC3100754 |
Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States R01 ES015597 / ES / NIEHS NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States ES015597 / ES / NIEHS NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States HL091062 / HL / NHLBI NIH HHS / United States R01 HL091062 / HL / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States |