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Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).

TitleGenome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
Publication TypeJournal Article
Year of Publication2011
AuthorsReiner AP, Lettre G, Nalls MA, Ganesh SK, Mathias R, Austin MA, Dean E, Arepalli S, Britton A, Chen Z, Couper D, J Curb D, Eaton CB, Fornage M, Grant SFA, Harris TB, Hernandez D, Kamatini N, Keating BJ, Kubo M, Lacroix A, Lange LA, Liu S, Lohman K, Meng Y, Mohler ER, Musani S, Nakamura Y, O'Donnell CJ, Okada Y, Palmer CD, Papanicolaou GJ, Patel KV, Singleton AB, Takahashi A, Tang H, Taylor HA, Taylor K, Thomson C, Yanek LR, Yang L, Ziv E, Zonderman AB, Folsom AR, Evans MK, Liu Y, Becker DM, Snively BM, Wilson JG
JournalPLoS Genet
Volume7
Issue6
Paginatione1002108
Date Published2011 Jun
ISSN1553-7404
KeywordsAfrican Americans, Artifacts, Asian Continental Ancestry Group, Chemokine CXCL2, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 4, DNA Replication, Duffy Blood-Group System, European Continental Ancestry Group, Genetic Loci, Genome-Wide Association Study, Humans, Leukocyte Count, Microfilament Proteins, Molecular Epidemiology, Phenotype, Polymorphism, Single Nucleotide, Receptors, Cell Surface, Reproducibility of Results
Abstract

Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived "null" variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recently associated with total WBC and WBC sub-type levels in European and Japanese populations. No additional loci that account for WBC variability have been identified in African Americans. In order to address this, we performed a large genome-wide association study (GWAS) of total WBC and cell subtype counts in 16,388 African-American participants from 7 population-based cohorts available in the Continental Origins and Genetic Epidemiology Network. In addition to the DARC locus on chromosome 1q23, we identified two other regions (chromosomes 4q13 and 16q22) associated with WBC in African Americans (P

DOI10.1371/journal.pgen.1002108
Alternate JournalPLoS Genet
PubMed ID21738479
PubMed Central IDPMC3128101
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01 AG062101 / AG / NIA NIH HHS / United States
1R01AG032098-01A1 / AG / NIA NIH HHS / United States
RR03655 / RR / NCRR NIH HHS / United States
N01-HC-95100 / HC / NHLBI NIH HHS / United States
44221 / / PHS HHS / United States
N01WH22110 / WH / WHI NIH HHS / United States
R01HL86694 / HL / NHLBI NIH HHS / United States
32105-6 / / PHS HHS / United States
N01-HC-45205 / HC / NHLBI NIH HHS / United States
Z01 AG000513 / / Intramural NIH HHS / United States
N01-HC-05187 / HC / NHLBI NIH HHS / United States
P41 RR003655 / RR / NCRR NIH HHS / United States
N01-HC-55017 / HC / NHLBI NIH HHS / United States
R01 HL087698 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
R01 NR008153 / NR / NINR NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
N01-HC-48047 / HC / NHLBI NIH HHS / United States
N01HC48049 / HL / NHLBI NIH HHS / United States
N01HC45205 / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
32118 / / PHS HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
42107-26 / / PHS HHS / United States
32115 / / PHS HHS / United States
N01-HC-45204 / HC / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
N01-HC-95095 / HC / NHLBI NIH HHS / United States
M01-RR000052 / RR / NCRR NIH HHS / United States
N01 AG062106 / AG / NIA NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
32100-2 / / PHS HHS / United States
24152 / / PHS HHS / United States
32119 / / PHS HHS / United States
N01-HC-48050 / HC / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
R01 AG032098 / AG / NIA NIH HHS / United States
N01HC95170 / HL / NHLBI NIH HHS / United States
HHSN268200782096C / HG / NHGRI NIH HHS / United States
42129-32 / / PHS HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
R01 HL71862-06 / HL / NHLBI NIH HHS / United States
N01HC95095 / HL / NHLBI NIH HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01 AG062103 / AG / NIA NIH HHS / United States
M01 RR000052 / RR / NCRR NIH HHS / United States
N01-HC-48049 / HC / NHLBI NIH HHS / United States
N01 HC045134 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
R01 HL071862 / HL / NHLBI NIH HHS / United States
U01 HL72518 / HL / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
32108-9 / / PHS HHS / United States
N01HC65226 / HL / NHLBI NIH HHS / United States
U01 HL072518 / HL / NHLBI NIH HHS / United States
N01-HC-95171 / HC / NHLBI NIH HHS / United States
N01HC48050 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
R01 HL087698-01 / HL / NHLBI NIH HHS / United States
N01HC05187 / HL / NHLBI NIH HHS / United States
R01 NR08153 / NR / NINR NIH HHS / United States
N01-HC-95172 / HC / NHLBI NIH HHS / United States
N01HC48047 / HL / NHLBI NIH HHS / United States
N01HC95171 / HL / NHLBI NIH HHS / United States
N01HC45204 / HL / NHLBI NIH HHS / United States
32122 / / PHS HHS / United States
N01-HC-48048 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
32111-13 / / PHS HHS / United States
N01-HC-95170 / HC / NHLBI NIH HHS / United States
N01HC48048 / HL / NHLBI NIH HHS / United States
N01-HC-65226 / HC / NHLBI NIH HHS / United States
N01HC95172 / HL / NHLBI NIH HHS / United States