Title | Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Reiner AP, Lettre G, Nalls MA, Ganesh SK, Mathias R, Austin MA, Dean E, Arepalli S, Britton A, Chen Z, Couper D, J Curb D, Eaton CB, Fornage M, Grant SFA, Harris TB, Hernandez D, Kamatini N, Keating BJ, Kubo M, Lacroix A, Lange LA, Liu S, Lohman K, Meng Y, Mohler ER, Musani S, Nakamura Y, O'Donnell CJ, Okada Y, Palmer CD, Papanicolaou GJ, Patel KV, Singleton AB, Takahashi A, Tang H, Taylor HA, Taylor K, Thomson C, Yanek LR, Yang L, Ziv E, Zonderman AB, Folsom AR, Evans MK, Liu Y, Becker DM, Snively BM, Wilson JG |
Journal | PLoS Genet |
Volume | 7 |
Issue | 6 |
Pagination | e1002108 |
Date Published | 2011 Jun |
ISSN | 1553-7404 |
Keywords | African Americans, Artifacts, Asians, Chemokine CXCL2, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 4, DNA Replication, Duffy Blood-Group System, Genetic Loci, Genome-Wide Association Study, Humans, Leukocyte Count, Microfilament Proteins, Molecular Epidemiology, Phenotype, Polymorphism, Single Nucleotide, Receptors, Cell Surface, Reproducibility of Results, Whites |
Abstract | Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived "null" variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recently associated with total WBC and WBC sub-type levels in European and Japanese populations. No additional loci that account for WBC variability have been identified in African Americans. In order to address this, we performed a large genome-wide association study (GWAS) of total WBC and cell subtype counts in 16,388 African-American participants from 7 population-based cohorts available in the Continental Origins and Genetic Epidemiology Network. In addition to the DARC locus on chromosome 1q23, we identified two other regions (chromosomes 4q13 and 16q22) associated with WBC in African Americans (P |
DOI | 10.1371/journal.pgen.1002108 |
Alternate Journal | PLoS Genet |
PubMed ID | 21738479 |
PubMed Central ID | PMC3128101 |
Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States N01 AG062101 / AG / NIA NIH HHS / United States 1R01AG032098-01A1 / AG / NIA NIH HHS / United States RR03655 / RR / NCRR NIH HHS / United States N01-HC-95100 / HC / NHLBI NIH HHS / United States 44221 / / PHS HHS / United States N01WH22110 / WH / WHI NIH HHS / United States R01HL86694 / HL / NHLBI NIH HHS / United States 32105-6 / / PHS HHS / United States N01-HC-45205 / HC / NHLBI NIH HHS / United States Z01 AG000513 / ImNIH / Intramural NIH HHS / United States N01-HC-05187 / HC / NHLBI NIH HHS / United States P41 RR003655 / RR / NCRR NIH HHS / United States N01-HC-55017 / HC / NHLBI NIH HHS / United States R01 HL087698 / HL / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States R01 NR008153 / NR / NINR NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States N01-HC-48047 / HC / NHLBI NIH HHS / United States N01HC48049 / HL / NHLBI NIH HHS / United States N01HC45205 / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States 32118 / / PHS HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States 42107-26 / / PHS HHS / United States 32115 / / PHS HHS / United States N01-HC-45204 / HC / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States N01-HC-95095 / HC / NHLBI NIH HHS / United States M01-RR000052 / RR / NCRR NIH HHS / United States N01 AG062106 / AG / NIA NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States HHSN268200625226C / / PHS HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States 32100-2 / / PHS HHS / United States 24152 / / PHS HHS / United States 32119 / / PHS HHS / United States N01-HC-48050 / HC / NHLBI NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States R01 AG032098 / AG / NIA NIH HHS / United States N01HC95170 / HL / NHLBI NIH HHS / United States HHSN268200782096C / HG / NHGRI NIH HHS / United States 42129-32 / / PHS HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States R01 HL71862-06 / HL / NHLBI NIH HHS / United States N01HC95095 / HL / NHLBI NIH HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01 AG062103 / AG / NIA NIH HHS / United States M01 RR000052 / RR / NCRR NIH HHS / United States N01-HC-48049 / HC / NHLBI NIH HHS / United States N01 HC045134 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States R01 HL071862 / HL / NHLBI NIH HHS / United States U01 HL72518 / HL / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States 32108-9 / / PHS HHS / United States N01HC65226 / HL / NHLBI NIH HHS / United States U01 HL072518 / HL / NHLBI NIH HHS / United States N01-HC-95171 / HC / NHLBI NIH HHS / United States N01HC48050 / HL / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States R01 HL087698-01 / HL / NHLBI NIH HHS / United States N01HC05187 / HL / NHLBI NIH HHS / United States R01 NR08153 / NR / NINR NIH HHS / United States N01-HC-95172 / HC / NHLBI NIH HHS / United States N01HC48047 / HL / NHLBI NIH HHS / United States N01HC95171 / HL / NHLBI NIH HHS / United States N01HC45204 / HL / NHLBI NIH HHS / United States 32122 / / PHS HHS / United States N01-HC-48048 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States 32111-13 / / PHS HHS / United States N01-HC-95170 / HC / NHLBI NIH HHS / United States N01HC48048 / HL / NHLBI NIH HHS / United States N01-HC-65226 / HC / NHLBI NIH HHS / United States N01HC95172 / HL / NHLBI NIH HHS / United States |