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Inverse association of eosinophil count with colorectal cancer incidence: atherosclerosis risk in communities study.

TitleInverse association of eosinophil count with colorectal cancer incidence: atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2011
AuthorsPrizment AE, Anderson KE, Visvanathan K, Folsom AR
JournalCancer Epidemiol Biomarkers Prev
Volume20
Issue9
Pagination1861-4
Date Published2011 Sep
ISSN1538-7755
KeywordsAged, Atherosclerosis, Colorectal Neoplasms, Eosinophils, Female, Humans, Incidence, Leukocyte Count, Male, Middle Aged, Prospective Studies, Risk Factors, United States
Abstract

BACKGROUND: Allergic conditions are associated with reduced risk of several malignancies. We hypothesized that blood eosinophil count, a marker for allergic disorders, is inversely associated with the risk of colorectal cancer (CRC) in the Atherosclerosis Risk in Communities prospective cohort. To our knowledge, the association between blood eosinophil count and cancer risk has not been investigated before.

METHODS: Relative eosinophil and total leukocyte counts were measured in blood at baseline. Absolute eosinophil counts were calculated by multiplying relative count by the total leukocyte count. Proportional hazards regression provided HRs and 95% CIs of CRC in relation to eosinophil count.

RESULTS: From 1987-2006, 242 incident CRC cases (187 colon and 56 rectal) occurred in 10,675 initially cancer-free participants. In a multivariate-adjusted model, HRs were 1.0, 0.70 (95% CI: 0.50-0.98) and 0.58 (95% CI: 0.40-0.83) across tertiles of absolute eosinophil count (P(trend) = 0.003). A similar inverse association was observed for relative eosinophil count. Age, sex, race, or smoking status did not modify associations.

CONCLUSIONS AND IMPACT: We observed an inverse association between blood eosinophil count and CRC risk. This novel finding supports the hypothesis that allergies are protective for CRC, as an increased eosinophil count correlates with allergy in the developed world.

DOI10.1158/1055-9965.EPI-11-0360
Alternate JournalCancer Epidemiol Biomarkers Prev
PubMed ID21742945
PubMed Central IDPMC3175810
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
T32CA132670 / CA / NCI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
T32 CA132670 / CA / NCI NIH HHS / United States