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Association between birthweight and cognitive function in middle age: the atherosclerosis risk in communities study.

TitleAssociation between birthweight and cognitive function in middle age: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2011
AuthorsCosta A J L, Kale P L, Luiz R R, de Moraes S A, Mosley TH, Szklo M
JournalAnn Epidemiol
Volume21
Issue11
Pagination851-6
Date Published2011 Nov
ISSN1873-2585
KeywordsAtherosclerosis, Birth Weight, Cognition Disorders, Cohort Studies, Female, Fetal Development, Humans, Male, Middle Aged, Risk Factors, United States
Abstract

PURPOSE: We aimed to examine the relationship of birthweight to cognitive performance in middle aged participants of the Atherosclerosis Risk in Communities Study (ARIC).

METHODS: Cognitive function, assessed by means of three neuropsychological tests-the Delayed Word Recall Test (DWR), the Digit Symbol Subtest of the Wechsler Adult Intelligence Scale-Revised (DSS/WAIS-R), and the Word Fluency (WF) Test, was evaluated in relation to birthweight, as recalled through standardized interviews, by the use of data from the second and fourth follow-up visits of the Atherosclerosis Risk in Communities study cohort (1990-1992 and 1996-1998, respectively). Overall, 6785 participants satisfied the inclusion criteria and were included in the analysis.

RESULTS: After adjusting for adult sociodemographic factors, childhood socioeconomic environment and parental risk factors, and adult anthropometric, health status-related. and behavioral variables, we observed linear trends for the relationship of birthweight to WF scores, although the trend was statistically significant only for those reporting exact birthweights (p for trend = .004). For the other cognitive test results, results were either null or inconsistent with the a priori hypotheses.

CONCLUSIONS: Except for WF in those reporting exact birthweights, our study does not support the notion that birthweight influences cognitive function in adults.

DOI10.1016/j.annepidem.2011.06.004
Alternate JournalAnn Epidemiol
PubMed ID21784656
PubMed Central IDPMC3190020
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States