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Does genetic ancestry explain higher values of glycated hemoglobin in African Americans?

TitleDoes genetic ancestry explain higher values of glycated hemoglobin in African Americans?
Publication TypeJournal Article
Year of Publication2011
AuthorsMaruthur NM, Kao LWH, Clark JM, Brancati FL, Cheng C-Y, Pankow JS, Selvin E
JournalDiabetes
Volume60
Issue9
Pagination2434-8
Date Published2011 Sep
ISSN1939-327X
KeywordsAfrican Americans, African Continental Ancestry Group, Blood Glucose, Cross-Sectional Studies, Female, Glycated Hemoglobin A, Humans, Male, Middle Aged, Prospective Studies
Abstract

OBJECTIVE: Glycated hemoglobin (HbA(1c)) values are higher in African Americans than whites, raising the question of whether classification of diabetes status by HbA(1c) should differ for African Americans. We investigated the relative contribution of genetic ancestry and nongenetic factors to HbA(1c) values and the effect of genetic ancestry on diabetes classification by HbA(1c) in African Americans.

RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of data from the community-based Atherosclerosis Risk in Communities (ARIC) Study. We estimated percentage of European genetic ancestry (PEA) for each of the 2,294 African Americans without known diabetes using 1,350 ancestry-informative markers. HbA(1c) was measured from whole-blood samples and categorized using American Diabetes Association diagnostic cut points (

RESULTS: PEA was inversely correlated with HbA(1c) (adjusted r = -0.07; P

CONCLUSIONS: The relative contribution of demographic and metabolic factors far outweighs the contribution of genetic ancestry to HbA(1c) values in African Americans. Moreover, the impact of adjusting for genetic ancestry when classifying diabetes by HbA(1c) is minimal after taking into account fasting glucose levels, thus supporting the use of currently recommended HbA(1c) categories for diagnosis of diabetes in African Americans.

DOI10.2337/db11-0319
Alternate JournalDiabetes
PubMed ID21788574
PubMed Central IDPMC3161314
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
K01 DK067207 / DK / NIDDK NIH HHS / United States
K01-DK-076595 / DK / NIDDK NIH HHS / United States
N01HV48195 / HL / NHLBI NIH HHS / United States
N01HG65403 / HG / NHGRI NIH HHS / United States
N01-HV-48195 / HV / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R21-DK-080294 / DK / NIDDK NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
1KL2-RR-025006-01 / RR / NCRR NIH HHS / United States
R21 DK073482 / DK / NIDDK NIH HHS / United States
R21-DK-073482 / DK / NIDDK NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
KL2 RR025006 / RR / NCRR NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
R21 DK080294 / DK / NIDDK NIH HHS / United States
K01-DK-067207 / DK / NIDDK NIH HHS / United States