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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

TitleGenome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Publication TypeJournal Article
Year of Publication2011
AuthorsArtigas MSoler, Loth DW, Wain LV, et al.
Secondary AuthorsTobin MD
Corporate AuthorsInternational Lung Cancer Consortium, GIANT consortium
JournalNat Genet
Volume43
Issue11
Pagination1082-90
Date Published2011 Sep 25
ISSN1546-1718
KeywordsChild, European Continental Ancestry Group, Genome-Wide Association Study, Humans, Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests
Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P

DOI10.1038/ng.941
Alternate JournalNat Genet
PubMed ID21946350
PubMed Central IDPMC3267376
Grant ListM01-RR00425 / RR / NCRR NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
079895 / WT_ / Wellcome Trust / United Kingdom
R01 ES015794 / ES / NIEHS NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
CZB/4/710 / / Chief Scientist Office / United Kingdom
CA55769 / CA / NCI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
N01-HC-45205 / HC / NHLBI NIH HHS / United States
R01 MH063706 / MH / NIMH NIH HHS / United States
CZD/16/6/2 / / Chief Scientist Office / United Kingdom
N01-HC-95162 / HC / NHLBI NIH HHS / United States
G0801056 / / Medical Research Council / United Kingdom
G0401540 / / Medical Research Council / United Kingdom
U19 CA148127 / CA / NCI NIH HHS / United States
R01 HL-071022 / HL / NHLBI NIH HHS / United States
MC_UP_A620_1015 / / Medical Research Council / United Kingdom
N01AG12100 / AG / NIA NIH HHS / United States
N01-HC-05187 / HC / NHLBI NIH HHS / United States
268201100011C / / PHS HHS / United States
R01 HL071251 / HL / NHLBI NIH HHS / United States
N01 HC-25195 / HC / NHLBI NIH HHS / United States
268201100005C / / PHS HHS / United States
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
MOP-82893 / CAPMC / CIHR / Canada
HHSN268201100010C / HL / NHLBI NIH HHS / United States
N01-HC-85085 / HC / NHLBI NIH HHS / United States
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