Title | Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects: the Atherosclerosis Risk in Communities (ARIC) Study. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Virani SS, Brautbar A, Davis BC, Nambi V, Hoogeveen RC, A Sharrett R, Coresh J, Mosley TH, Morrisett JD, Catellier DJ, Folsom AR, Boerwinkle E, Ballantyne CM |
Journal | Circulation |
Volume | 125 |
Issue | 2 |
Pagination | 241-9 |
Date Published | 2012 Jan 17 |
ISSN | 1524-4539 |
Keywords | Adult, Aged, Atherosclerosis, Blacks, Cardiovascular Diseases, Coronary Disease, Female, Follow-Up Studies, Humans, Incidence, Lipoprotein(a), Male, Middle Aged, Prognosis, Risk, Stroke, Whites |
Abstract | BACKGROUND: On the basis of studies with limited statistical power, lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study. METHODS AND RESULTS: Plasma Lp(a) was measured in blacks (n=3467) and whites (n=9851). Hazards ratios (HRs) for incident CVD events (coronary heart disease and ischemic strokes) were calculated. Lp(a) levels were higher with wider interindividual variation in blacks (median [interquartile range], 12.8 [7.1-21.7] mg/dL) than whites (4.3 [1.7-9.5] mg/dL; P10 to ≤20 mg/dL, >20 to ≤30 mg/dL, and >30 mg/dL. CONCLUSIONS: Lp(a) levels were positively associated with CVD events. Associations were at least as strong, with a larger range of Lp(a) concentrations, in blacks compared with whites. |
DOI | 10.1161/CIRCULATIONAHA.111.045120 |
Alternate Journal | Circulation |
PubMed ID | 22128224 |
PubMed Central ID | PMC3760720 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States K23 HL096893 / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States CDA 09-028 / HX / HSRD VA / United States 5K23HL096893-02 / HL / NHLBI NIH HHS / United States K23 HL096893-02 / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States |