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Glycated hemoglobin and cancer incidence and mortality in the Atherosclerosis in Communities (ARIC) Study, 1990-2006.

TitleGlycated hemoglobin and cancer incidence and mortality in the Atherosclerosis in Communities (ARIC) Study, 1990-2006.
Publication TypeJournal Article
Year of Publication2012
AuthorsJoshu CE, Prizment AE, Dluzniewski PJ, Menke A, Folsom AR, Coresh JJ, Yeh HC, Brancati FL, Platz EA
Secondary AuthorsSelvin E
JournalInt J Cancer
Volume131
Issue7
Pagination1667-77
Date Published2012 Oct 01
ISSN1097-0215
KeywordsAtherosclerosis, Diabetes Mellitus, Female, Glycated Hemoglobin A, Humans, Incidence, Male, Middle Aged, Neoplasms, Risk Factors
Abstract

Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of 12,792 cancer-free participants attending the second visit (1990-1992) of the Atherosclerosis Risk in Communities (ARIC) Study. We measured glycated hemoglobin in whole-blood samples using HPLC. Incident cancers were ascertained from registries and hospital records through 2006. We estimated multivariable-adjusted hazard ratios (HR) of cancer incidence and mortality for nondiabetic participants with values ≥ 5.7% (elevated), nondiabetic participants with

DOI10.1002/ijc.27394
Alternate JournalInt J Cancer
PubMed ID22161730
PubMed Central IDPMC3906204
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
T32CA009314 / CA / NCI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
R21 DK080294-01 / DK / NIDDK NIH HHS / United States
K01 DK076595-01 / DK / NIDDK NIH HHS / United States
R01 DK089174-01A1 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
T32 CA009314-25 / CA / NCI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
T32 CA132670 / CA / NCI NIH HHS / United States
R21 DK080294 / DK / NIDDK NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
T32 CA132670-04 / CA / NCI NIH HHS / United States
T32 CA009314 / CA / NCI NIH HHS / United States