Title | Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Bezerra DC, Sharrett AR, Matsushita K, Gottesman RF, Shibata D, Mosley TH, Coresh J, Szklo M, Carvalho MS, Selvin E |
Journal | Neurology |
Volume | 78 |
Issue | 2 |
Pagination | 102-8 |
Date Published | 2012 Jan 10 |
ISSN | 1526-632X |
Keywords | Atherosclerosis, Brain, Cholesterol, HDL, Cross-Sectional Studies, Diabetes Mellitus, Ethnicity, Female, Follow-Up Studies, Glycated Hemoglobin A, Humans, Hypertension, Magnetic Resonance Imaging, Male, Middle Aged, Models, Statistical, Prevalence, Residence Characteristics, Risk Factors, Stroke, Lacunar |
Abstract | OBJECTIVE: Lacunar infarctions are mainly due to 2 microvascular pathologies: lipohyalinosis and microatheroma. Little is known about risk factor differences for these subtypes. We hypothesized that diabetes and glycated hemoglobin (HbA(1)c) would be related preferentially to the lipohyalinotic subtype. METHODS: We performed a cross-section analysis of the brain MRI data from 1,827 participants in the Atherosclerosis Risk in Communities study. We divided subcortical lesions ≤ 20 mm in diameter into those ≤ 7 mm (of probable lipohyalinotic etiology) and 8-20 mm (probably due to microatheroma) and used Poisson regression to investigate associations with the number of each type of lesion. Unlike previous studies, we also fitted a model involving lesions RESULTS: Age (prevalence ratio [PR] 1.11 per year; 95% confidence interval [CI] 1.08-1.14), black ethnicity (vs white, PR 1.66; 95% CI 1.27-2.16), hypertension (PR 2.12; 95% CI 1.61-2.79), diabetes (PR 1.42; 95% CI 1.08-1.87), and ever-smoking (PR 1.34; 95% CI 1.04-1.74) were significantly associated with lesions ≤ 7 mm. Findings were similar for lesions CONCLUSIONS: Smaller lacunes (even those |
DOI | 10.1212/WNL.0b013e31823efc42 |
Alternate Journal | Neurology |
PubMed ID | 22170882 |
PubMed Central ID | PMC3466671 |
Grant List | HHSN268201100009C / / PHS HHS / United States HHSN268201100010C / / PHS HHS / United States HHSN268201100008C / / PHS HHS / United States HHSN268201100012C / / PHS HHS / United States HHSN268201100007C / / PHS HHS / United States HSN268201100005C / / PHS HHS / United States HHSN268201100011C / / PHS HHS / United States HHSN268201100006C / / PHS HHS / United States |