Title | Blood lipid levels, lipid-lowering medications, and the incidence of atrial fibrillation: the atherosclerosis risk in communities study. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Lopez FL, Agarwal SK, Maclehose RF, Soliman EZ, A Sharrett R, Huxley RR, Konety S, Ballantyne CM, Alonso A |
Journal | Circ Arrhythm Electrophysiol |
Volume | 5 |
Issue | 1 |
Pagination | 155-62 |
Date Published | 2012 Feb |
ISSN | 1941-3084 |
Keywords | Atherosclerosis, Atrial Fibrillation, Biomarkers, Female, Follow-Up Studies, Humans, Hypolipidemic Agents, Incidence, Lipids, Male, Middle Aged, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, United States |
Abstract | BACKGROUND: Several cardiovascular risk factors have been associated with the risk of atrial fibrillation (AF). Limited and inconsistent evidence exists on the association of blood lipid levels and lipid-lowering medication use with AF risk. METHODS AND RESULTS: We analyzed 13 969 participants (25% African American, 45% men) free of AF at baseline from the Atherosclerosis Risk in Communities study. Fasting high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides, and total cholesterol were measured at baseline (1987-1989) and each of 3 follow-up visits. The incidence of AF was ascertained through 2007. The association of the use of statins and other lipid-lowering medications with AF was estimated in 13 044 Atherosclerosis Risk in Communities participants attending visit 2 (1990-1992), adjusting for covariates from the previous visit. During a median follow-up of 18.7 years, there were 1433 incident AF cases. Multivariable hazard ratios (HRs) and 95% CIs of AF associated with a 1-SD increase in lipid levels were as follows: HDLc, 0.97 (0.91-1.04); LDLc, 0.90 (0.85-0.96); total cholesterol, 0.89 (0.84-0.95); and triglycerides, 1.00 (0.96-1.04). Participants taking lipid-lowering medications had an adjusted HR (95% CI) of AF of 0.96 (0.82-1.13) compared with those not taking medications, whereas those taking statins had an adjusted HR of 0.91 (0.66-1.25) compared with those taking other lipid-lowering medications. CONCLUSIONS: Higher levels of LDLc and total cholesterol were associated with a lower incidence of AF. However, HDLc and triglycerides were not independently associated with AF incidence. No association was found between the use of lipid-lowering medications and incident AF. |
DOI | 10.1161/CIRCEP.111.966804 |
Alternate Journal | Circ Arrhythm Electrophysiol |
PubMed ID | 22227953 |
PubMed Central ID | PMC3290134 |
Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States N01-HC55021 / HC / NHLBI NIH HHS / United States 09SDG2280087 / / PHS HHS / United States N01-HC55015 / HC / NHLBI NIH HHS / United States N01 HC055018 / HC / NHLBI NIH HHS / United States RC1 HL099452 / HL / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01-HC55019 / HC / NHLBI NIH HHS / United States N01 HC055019 / HC / NHLBI NIH HHS / United States RC1-HL099452 / HL / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States RC1 HL099452-01 / HL / NHLBI NIH HHS / United States N01 HC055016 / HC / NHLBI NIH HHS / United States N01-HC55020 / HC / NHLBI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01-HC55022 / HC / NHLBI NIH HHS / United States N01-HC55018 / HC / NHLBI NIH HHS / United States N01 HC055015 / HC / NHLBI NIH HHS / United States N01-HC55016 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States |