Pulse lineResearch With Heart Logo

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

TitleMeta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Publication TypeJournal Article
Year of Publication2012
AuthorsStolk L, Perry JRB, Chasman DI, et al.
Secondary AuthorsLunetta KL
Corporate AuthorsLifeLines Cohort Study
JournalNat Genet
Volume44
Issue3
Pagination260-8
Date Published2012 Jan 22
ISSN1546-1718
KeywordsAge Factors, DNA Helicases, DNA Polymerase gamma, DNA Primase, DNA Repair, DNA Repair Enzymes, DNA-Directed DNA Polymerase, European Continental Ancestry Group, Exodeoxyribonucleases, Female, Genetic Loci, Genome-Wide Association Study, Humans, Immunity, Menopause, Polymorphism, Single Nucleotide, Proteins
Abstract

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P

DOI10.1038/ng.1051
Alternate JournalNat Genet
PubMed ID22267201
PubMed Central IDPMC3288642
Grant ListCZB/4/710 / CSO_ / Chief Scientist Office / United Kingdom
N01 HC085086 / HC / NHLBI NIH HHS / United States
G0600705 / MRC_ / Medical Research Council / United Kingdom
R01 CA047988-09 / CA / NCI NIH HHS / United States
MC_U127561128 / MRC_ / Medical Research Council / United Kingdom
N02 HL64278 / HL / NHLBI NIH HHS / United States
U01 HL084756 / HL / NHLBI NIH HHS / United States
N01 AG050002 / AG / NIA NIH HHS / United States
R01 CA047988 / CA / NCI NIH HHS / United States
G0700704 / MRC_ / Medical Research Council / United Kingdom
U01 HL084756-01 / HL / NHLBI NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
R69/0208 / DMT_ / The Dunhill Medical Trust / United Kingdom
K05 AA017688 / AA / NIAAA NIH HHS / United States
N01 AG012100 / AG / NIA NIH HHS / United States
R01 HL105756-01 / HL / NHLBI NIH HHS / United States
U01 HG004402-01 / HG / NHGRI NIH HHS / United States
P01 CA087969 / CA / NCI NIH HHS / United States
R21 AG032598-01 / AG / NIA NIH HHS / United States
R01 HL087660 / HL / NHLBI NIH HHS / United States
R01 AR041398-09 / AR / NIAMS NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
R01 HL087660-01 / HL / NHLBI NIH HHS / United States
R01 AR041398 / AR / NIAMS NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
263 MD821336 / MD / NIMHD NIH HHS / United States
263 MD9164 13 / MD / NIMHD NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 CA040356-15 / CA / NCI NIH HHS / United States
P30 DK072488 / DK / NIDDK NIH HHS / United States
MC_PC_U127592696 / MRC_ / Medical Research Council / United Kingdom
N01 AG012109 / AG / NIA NIH HHS / United States
MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom
U01 HL072515 / HL / NHLBI NIH HHS / United States
R01 HL043851-09 / HL / NHLBI NIH HHS / United States
U01 CA098233 / CA / NCI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
U01 HL072515-01 / HL / NHLBI NIH HHS / United States
R21 AG032598 / AG / NIA NIH HHS / United States
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
U01 CA098233-01 / CA / NCI NIH HHS / United States
P01 CA087969-12 / CA / NCI NIH HHS / United States
MC_U127592696 / MRC_ / Medical Research Council / United Kingdom