Title | Chronic hyperglycemia and subclinical myocardial injury. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Rubin J, Matsushita K, Ballantyne CM, Hoogeveen R, Coresh J, Selvin E |
Journal | J Am Coll Cardiol |
Volume | 59 |
Issue | 5 |
Pagination | 484-9 |
Date Published | 2012 Jan 31 |
ISSN | 1558-3597 |
Keywords | Biomarkers, Blood Glucose, Chronic Disease, Coronary Disease, Disease Progression, Female, Follow-Up Studies, Glycated Hemoglobin A, Humans, Hyperglycemia, Incidence, Male, Middle Aged, Myocardium, Odds Ratio, Prevalence, Prognosis, Prospective Studies, Risk Factors, Troponin T, United States |
Abstract | OBJECTIVES: The purpose of this study was to examine the association between hyperglycemia and subclinical myocardial injury in persons without clinically evident coronary heart disease (CHD). BACKGROUND: Hyperglycemia is associated with an increased risk of cardiac events, but limited information is available on its relationship to subclinical myocardial damage. Elevated cardiac troponin T even below traditional detection levels can be detected by a novel high-sensitivity assay. METHODS: We examined the association between baseline glycated hemoglobin (HbA1c) and high-sensitivity cardiac troponin T (hs-cTnT) in 9,661 participants free of CHD and heart failure in the ARIC (Atherosclerosis Risk in Communities) study. Multivariable logistic regression models characterized the association between clinical categories of HbA1c ( RESULTS: Higher baseline values of HbA1c were associated in a graded fashion with elevated hs-cTnT (p for trend CONCLUSIONS: Higher HbA1c is associated with elevated hs-cTnT among persons without clinically evident CHD, suggesting that hyperglycemia contributes to myocardial injury beyond its effects on development of clinical atherosclerotic coronary disease. |
DOI | 10.1016/j.jacc.2011.10.875 |
Alternate Journal | J Am Coll Cardiol |
PubMed ID | 22281251 |
PubMed Central ID | PMC3267958 |
Grant List | K01 DK076595-03 / DK / NIDDK NIH HHS / United States K01 DK076595-04 / DK / NIDDK NIH HHS / United States T32 HL007024 / HL / NHLBI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States K01 DK076595 / DK / NIDDK NIH HHS / United States K01 DK076595-05 / DK / NIDDK NIH HHS / United States R21 DK080294-01 / DK / NIDDK NIH HHS / United States K01 DK076595-01 / DK / NIDDK NIH HHS / United States R01 DK076770 / DK / NIDDK NIH HHS / United States R21 DK080294-02 / DK / NIDDK NIH HHS / United States K01 DK076595-02 / DK / NIDDK NIH HHS / United States R21 DK080294 / DK / NIDDK NIH HHS / United States |