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Chronic hyperglycemia and subclinical myocardial injury.

TitleChronic hyperglycemia and subclinical myocardial injury.
Publication TypeJournal Article
Year of Publication2012
AuthorsRubin J, Matsushita K, Ballantyne CM, Hoogeveen RC, Coresh JJ
Secondary AuthorsSelvin E
JournalJ Am Coll Cardiol
Volume59
Issue5
Pagination484-9
Date Published2012 Jan 31
ISSN1558-3597
KeywordsBiomarkers, Blood Glucose, Chronic Disease, Coronary Disease, Disease Progression, Female, Follow-Up Studies, Glycated Hemoglobin A, Humans, Hyperglycemia, Incidence, Male, Middle Aged, Myocardium, Odds Ratio, Prevalence, Prognosis, Prospective Studies, Risk Factors, Troponin T, United States
Abstract

OBJECTIVES: The purpose of this study was to examine the association between hyperglycemia and subclinical myocardial injury in persons without clinically evident coronary heart disease (CHD).

BACKGROUND: Hyperglycemia is associated with an increased risk of cardiac events, but limited information is available on its relationship to subclinical myocardial damage. Elevated cardiac troponin T even below traditional detection levels can be detected by a novel high-sensitivity assay.

METHODS: We examined the association between baseline glycated hemoglobin (HbA1c) and high-sensitivity cardiac troponin T (hs-cTnT) in 9,661 participants free of CHD and heart failure in the ARIC (Atherosclerosis Risk in Communities) study. Multivariable logistic regression models characterized the association between clinical categories of HbA1c (

RESULTS: Higher baseline values of HbA1c were associated in a graded fashion with elevated hs-cTnT (p for trend

CONCLUSIONS: Higher HbA1c is associated with elevated hs-cTnT among persons without clinically evident CHD, suggesting that hyperglycemia contributes to myocardial injury beyond its effects on development of clinical atherosclerotic coronary disease.

DOI10.1016/j.jacc.2011.10.875
Alternate JournalJ Am Coll Cardiol
PubMed ID22281251
PubMed Central IDPMC3267958
Grant ListK01 DK076595-03 / DK / NIDDK NIH HHS / United States
K01 DK076595-04 / DK / NIDDK NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
K01 DK076595-05 / DK / NIDDK NIH HHS / United States
R21 DK080294-01 / DK / NIDDK NIH HHS / United States
K01 DK076595-01 / DK / NIDDK NIH HHS / United States
R01 DK076770 / DK / NIDDK NIH HHS / United States
R21 DK080294-02 / DK / NIDDK NIH HHS / United States
K01 DK076595-02 / DK / NIDDK NIH HHS / United States
R21 DK080294 / DK / NIDDK NIH HHS / United States