|Title||Body mass index at age 25 and all-cause mortality in whites and African Americans: the Atherosclerosis Risk in Communities study.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Stevens J, Truesdale KP, Wang C-H, Cai J|
|Secondary Authors||Erber E|
|Journal||J Adolesc Health|
|Date Published||2012 Mar|
|Keywords||Adult, African Americans, Alcohol Drinking, Atherosclerosis, Body Mass Index, Body Weight, European Continental Ancestry Group, Female, Humans, Male, Middle Aged, Overweight, Proportional Hazards Models, Smoking|
PURPOSE: Approximately 20% of young adults in the United States are obese, and most of them gain weight between young and middle adulthood. Few studies have examined the association between elevated body mass index (BMI) in early adulthood and mortality or have examined that such effects are independent of changes in weight. To our knowledge, no such study has been conducted in African-American samples.
METHODS: We used data from 13,941 African-American and white adults who self-reported their weight at the age of 25, and had weight and height measured when they were 45-64 years of age (1987-1989). Date of death was ascertained between 1987 and 2005. Hazard ratios and hazard differences for the effects of BMI at age 25 on all-cause mortality were determined using Cox proportional hazard and additive hazard models, respectively.
RESULTS: In the combined ethnic-gender groups, the hazard ratio associated with a 5 kg/m(2) increase in BMI at age 25 was 1.28 (95% confidence interval [CI]: 1.22-1.35), and the hazard difference was 2.75 (2.01-3.50) deaths/1,000 person-years. Associations were observed in all four ethnic-gender groups. Models including weight change from age 25 to age in 1987-1989 resulted in null estimates for BMI in African-American men, whereas associations were maintained or only mildly attenuated in other ethnic-gender groups.
CONCLUSIONS: Excess weight during young adulthood should be avoided because it contributes to increases in death rates that may be independent of changes in weight experienced in later life. Further study is needed to better understand these associations in African-American men.
|Alternate Journal||J Adolesc Health|
|PubMed Central ID||PMC3279701|
|Grant List||N01HC55020 / HL / NHLBI NIH HHS / United States |
N01 HC055022 / HC / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
RC1 HL099429 / HL / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
R24 HD050924 / HD / NICHD NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
N01 HC055016 / HC / NHLBI NIH HHS / United States