Title | The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Nambi V, Boerwinkle E, Lawson K, Brautbar A, Chambless L, Franeschini N, North KE, Virani SS, Folsom AR, Ballantyne CM |
Journal | Atherosclerosis |
Volume | 222 |
Issue | 1 |
Pagination | 135-7 |
Date Published | 2012 May |
ISSN | 1879-1484 |
Keywords | Carotid Intima-Media Thickness, Chromosomes, Human, Pair 9, Coronary Disease, Humans, Plaque, Atherosclerotic, Polymorphism, Single Nucleotide, Risk, Risk Factors, ROC Curve, Whites |
Abstract | OBJECTIVE: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. METHODS: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n=9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated. RESULTS: The AUC of the ACRS, ACRS+9p21, ACRS+CIMT-P and ACRS+CIMT-P+9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript). CONCLUSION: Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study. |
DOI | 10.1016/j.atherosclerosis.2012.01.028 |
Alternate Journal | Atherosclerosis |
PubMed ID | 22349088 |
PubMed Central ID | PMC3334435 |
Grant List | HHSN268201100009I / HL / NHLBI NIH HHS / United States R01 HL059367-11 / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States UL1 RR024148 / RR / NCRR NIH HHS / United States U01 HG004402-02S1 / HG / NHGRI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States R01HL086694 / HL / NHLBI NIH HHS / United States HHSN268201100012C / HL / NHLBI NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States UL1 RR025005-05 / RR / NCRR NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States K23 HL096893-03 / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States R01 HL086694-05 / HL / NHLBI NIH HHS / United States HHSN268200625226C / / PHS HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States K23 HL096893 / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States R01 HL087641-01 / HL / NHLBI NIH HHS / United States |