Title | No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Scott RA, Chu AY, Grarup N, et al. |
Journal | Diabetes |
Volume | 61 |
Issue | 5 |
Pagination | 1291-6 |
Date Published | 2012 May |
ISSN | 1939-327X |
Keywords | Blood Glucose, Body Mass Index, Epigenesis, Genetic, Gene Expression Regulation, Genotype, Humans, Life Style, Motor Activity, Polymorphism, Single Nucleotide |
Abstract | Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. |
DOI | 10.2337/db11-0973 |
Alternate Journal | Diabetes |
PubMed ID | 22415877 |
PubMed Central ID | PMC3331745 |
Grant List | MC_UP_A620_1015 / MRC_ / Medical Research Council / United Kingdom MC_UP_A100_1003 / MRC_ / Medical Research Council / United Kingdom G19/35 / MRC_ / Medical Research Council / United Kingdom G0100222 / MRC_ / Medical Research Council / United Kingdom T32 HL007575 / HL / NHLBI NIH HHS / United States MC_UP_A620_1014 / MRC_ / Medical Research Council / United Kingdom MC_U106179471 / MRC_ / Medical Research Council / United Kingdom P30 DK063491 / DK / NIDDK NIH HHS / United States G1002084 / MRC_ / Medical Research Council / United Kingdom UL1 RR024148 / RR / NCRR NIH HHS / United States P30 DK020572 / DK / NIDDK NIH HHS / United States MC_U147585824 / MRC_ / Medical Research Council / United Kingdom RG/07/008/23674 / BHF_ / British Heart Foundation / United Kingdom G8802774 / MRC_ / Medical Research Council / United Kingdom R01 DK072041 / DK / NIDDK NIH HHS / United States T32 HG000040 / HG / NHGRI NIH HHS / United States G0902037 / MRC_ / Medical Research Council / United Kingdom UL1 RR025741 / RR / NCRR NIH HHS / United States MC_U106179473 / MRC_ / Medical Research Council / United Kingdom UL1 TR000124 / TR / NCATS NIH HHS / United States G0701863 / MRC_ / Medical Research Council / United Kingdom K24 DK080140 / DK / NIDDK NIH HHS / United States |