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A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.

TitleA meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
Publication TypeJournal Article
Year of Publication2012
AuthorsQayyum R, Snively BM, Ziv E, Nalls MA, Liu Y, Tang W, Yanek LR, Lange L, Evans MK, Ganesh S, Austin MA, Lettre G, Becker DM, Zonderman AB, Singleton AB, Harris TB, Mohler ER, Logsdon BA, Kooperberg C, Folsom AR, Wilson JG, Becker LC
Secondary AuthorsReiner AP
JournalPLoS Genet
Volume8
Issue3
Paginatione1002491
Date Published2012
ISSN1553-7404
KeywordsAdult, African Americans, Aged, Blood Platelets, Female, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Platelet Aggregation, Platelet Count, Polymorphism, Single Nucleotide
Abstract

Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of European ancestry. In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to identify novel genetic variants associated with platelet count and MPV. For all cohorts, GWAS analysis was performed using additive models after adjusting for age, sex, and population stratification. For both platelet phenotypes, meta-analyses were conducted using inverse-variance weighted fixed-effect models. Platelet aggregation assays in whole blood were performed in the participants of the GeneSTAR cohort. Genetic variants in ten independent regions were associated with platelet count (N = 16,388) with p

DOI10.1371/journal.pgen.1002491
Alternate JournalPLoS Genet
PubMed ID22423221
PubMed Central IDPMC3299192
Grant ListHHSN268201100009I / HL / NHLBI NIH HHS / United States
Z01 AG000513 / / Intramural NIH HHS / United States
R01 HL087698 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
R01 AG032098 / AG / NIA NIH HHS / United States
N01HC95095 / HL / NHLBI NIH HHS / United States
1K23HL105897-01 / HL / NHLBI NIH HHS / United States
U01 HL072518 / HL / NHLBI NIH HHS / United States
U01 HG005157 / HG / NHGRI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
N01HC45204 / HL / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
U01 HG005152 / HG / NHGRI NIH HHS / United States
N01WH22110 / WH / WHI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
N01 AG062101 / AG / NIA NIH HHS / United States
P30 CA015704 / CA / NCI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
N01HC48049 / HL / NHLBI NIH HHS / United States
N01HC45205 / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
U01 HG004424 / HG / NHGRI NIH HHS / United States
K23 HL105897 / HL / NHLBI NIH HHS / United States
N01 AG062106 / AG / NIA NIH HHS / United States
N01HC95170 / HL / NHLBI NIH HHS / United States
HHSN268200782096C / HG / NHGRI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
R01 HL71862-06 / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
N01 AG062103 / AG / NIA NIH HHS / United States
N01 HC045134 / HC / NHLBI NIH HHS / United States
R01 HL071862 / HL / NHLBI NIH HHS / United States
N01HC65226 / HL / NHLBI NIH HHS / United States
N01HC48050 / HL / NHLBI NIH HHS / United States
N01HC05187 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
N01HC48047 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
N01HC95171 / HL / NHLBI NIH HHS / United States
N01HC48048 / HL / NHLBI NIH HHS / United States
N01HC95172 / HL / NHLBI NIH HHS / United States