|Title||Occupation and three-year incidence of respiratory symptoms and lung function decline: the ARIC Study.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Mirabelli MC, London SJ, Charles LE, Pompeii LA|
|Secondary Authors||Wagenknecht LE|
|Date Published||2012 Mar 20|
|Keywords||Asthma, Atherosclerosis, Bronchitis, Chronic, Cohort Studies, Cough, Female, Follow-Up Studies, Humans, Incidence, Longitudinal Studies, Lung, Lung Diseases, Male, Middle Aged, Occupational Diseases, Occupations, Prospective Studies, Respiratory Function Tests, Risk Factors|
BACKGROUND: Specific occupations are associated with adverse respiratory health. Inhalation exposures encountered in these jobs may place workers at risk of new-onset respiratory disease.
METHODS: We analyzed data from 8,967 participants from the Atherosclerosis Risk in Communities (ARIC) study, a longitudinal cohort study. Participants included in this analysis were free of chronic cough and phlegm, wheezing, asthma, chronic bronchitis, emphysema, and other chronic lung conditions at the baseline examination, when they were aged 45-64 years. Using data collected in the baseline and first follow-up examination, we evaluated associations between occupation and the three-year incidence of cough, phlegm, wheezing, and airway obstruction and changes in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) measured by spirometry. All associations were adjusted for age, cigarettes per day, race, smoking status, and study center.
RESULTS: During the approximately three-year follow-up, the percentage of participants developing chronic cough was 3%; chronic phlegm, 3%; wheezing, 3%; and airway obstruction, defined as FEV1
CONCLUSIONS: Employment in mechanic and repair jobs and cleaning and building service occupations are associated with increased incidence of respiratory symptoms. Specific occupations affect the respiratory health of adults without pre-existing respiratory health symptoms and conditions, though long-term health consequences of inhalation exposures in these jobs remain largely unexplored.
|Alternate Journal||Respir Res|
|PubMed Central ID||PMC3352304|
|Grant List||HHSN268201100005C / / PHS HHS / United States |
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
/ / Intramural NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States