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African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts.

TitleAfrican ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts.
Publication TypeJournal Article
Year of Publication2012
AuthorsCheng C-Y, Reich D, Haiman CA, Tandon A, Patterson N, Selvin E, Elizabeth S, Akylbekova EL, Brancati FL, Coresh JJ, Boerwinkle E, Altshuler D, Taylor HA, Henderson BE, Wilson JG
Secondary AuthorsKao LWH
JournalPLoS One
Volume7
Issue3
Paginatione32840
Date Published2012
ISSN1932-6203
KeywordsAdult, African Americans, Aged, Animals, Cohort Studies, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Markers, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Odds Ratio, Prospective Studies, Quantitative Trait, Heritable, Risk Factors, United States, Young Adult
Abstract

The risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that genetic factors may explain some of this population difference in disease risk. However, relatively few genetic studies have examined this hypothesis in a large sample of African Americans with and without diabetes. Therefore, we performed an admixture analysis using 2,189 ancestry-informative markers in 7,021 African Americans (2,373 with type 2 diabetes and 4,648 without) from the Atherosclerosis Risk in Communities Study, the Jackson Heart Study, and the Multiethnic Cohort to 1) determine the association of type 2 diabetes and its related quantitative traits with African ancestry controlling for measures of SES and 2) identify genetic loci for type 2 diabetes through a genome-wide admixture mapping scan. The median percentage of African ancestry of diabetic participants was slightly greater than that of non-diabetic participants (study-adjusted difference = 1.6%, P

DOI10.1371/journal.pone.0032840
Alternate JournalPLoS One
PubMed ID22438884
PubMed Central IDPMC3306373
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
CA54281 / CA / NCI NIH HHS / United States
K01 DK067207 / DK / NIDDK NIH HHS / United States
N01HV48195 / HL / NHLBI NIH HHS / United States
N01HG65403 / HG / NHGRI NIH HHS / United States
N01-HV-48195 / HV / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
U01 HG004168 / HG / NHGRI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
R21DK073482 / DK / NIDDK NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
R01-HL-084107 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
CA63464 / CA / NCI NIH HHS / United States
K01DK067207 / DK / NIDDK NIH HHS / United States
N01HC95170 / HL / NHLBI NIH HHS / United States
P60DK079637 / DK / NIDDK NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
R01 HL084107 / HL / NHLBI NIH HHS / United States
R21 DK073482 / DK / NIDDK NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
R01 CA063464 / CA / NCI NIH HHS / United States
P60 DK079637 / DK / NIDDK NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R01 CA054281 / CA / NCI NIH HHS / United States
N01-HC-95171 / HC / NHLBI NIH HHS / United States
U01 CA063464 / CA / NCI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-95172 / HC / NHLBI NIH HHS / United States
N01HC95171 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
N01-HC-95170 / HC / NHLBI NIH HHS / United States
R37 CA054281 / CA / NCI NIH HHS / United States
U01-HG004168 / HG / NHGRI NIH HHS / United States
N01HC95172 / HL / NHLBI NIH HHS / United States