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Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.

TitleOrthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.
Publication TypeJournal Article
Year of Publication2012
AuthorsFedorowski A, Franceschini N, Brody J, Liu C, Verwoert GC, Boerwinkle E, Couper DJ, Rice KM, Rotter JI, Mattace-Raso F, Uitterlinden A, Hofman A, Almgren P, Sjögren M, Hedblad B, Larson MG, Newton-Cheh C, Wang TJ, Rose KM, Psaty BM, Levy D, Witteman J
Secondary AuthorsMelander O
JournalEur Heart J
Volume33
Issue18
Pagination2331-41
Date Published2012 Sep
ISSN1522-9645
KeywordsAged, Antihypertensive Agents, Atherosclerosis, Blood Pressure, Epidemiologic Methods, Female, Gene Frequency, Heterozygote, Homozygote, Humans, Hypotension, Orthostatic, Male, Middle Aged, Polymorphism, Single Nucleotide
Abstract

AIMS: Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their impact on OH remains unknown.

METHODS AND RESULTS: A total of 38 970 men and women of European ancestry from five population-based cohorts were included, of whom 2656 (6.8%) met the diagnostic criteria for OH (systolic/diastolic BP drop ≥ 20/10 mmHg within 3 min of standing). Thirty-one recently discovered BP-associated single nucleotide polymorphisms (SNPs) were examined using an additive genetic model and the major allele as referent. Relations between OH, orthostatic systolic BP response, and genetic variants were assessed by inverse variance-weighted meta-analysis. We found Bonferroni adjusted (P

CONCLUSION: The overall association between common gene variants in BP loci and OH was generally weak and the direction of effect inconsistent with resting BP findings. These results suggest that OH and resting BP share few genetic components.

DOI10.1093/eurheartj/ehs058
Alternate JournalEur Heart J
PubMed ID22504314
PubMed Central IDPMC3442958
Grant ListP30 DK063491 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
UL1 RR024148 / RR / NCRR NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States