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Common variants at 12q14 and 12q24 are associated with hippocampal volume.

TitleCommon variants at 12q14 and 12q24 are associated with hippocampal volume.
Publication TypeJournal Article
Year of Publication2012
AuthorsBis JC, DeCarli C, Smith A V, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi S-H, Sigurdsson S, Verhaaren BFJ, DeStefano AL, Lambert J-C, Jack CR, Struchalin M, Stankovich J, Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, Heijer Tden, Mazoyer B, Coker LH, Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RFAG, Beiser A, Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK, Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland SE, Vasquez AArias, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM, Nalls MA, Uitterlinden AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V, Breteler MMB, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA, van der Lugt A, Gudnason V, Longstreth WT, Brown MA, Bennett DA, van Duijn CM, Mosley TH, Schmidt R, Tzourio C, Launer LJ, M Ikram A
Secondary AuthorsSeshadri S
Corporate AuthorsEnhancing Neuro Imaging Genetics through Meta-Analysis Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
JournalNat Genet
Volume44
Issue5
Pagination545-51
Date Published2012 Apr 15
ISSN1546-1718
KeywordsAlzheimer Disease, Chromosomes, Human, Pair 12, Cognition Disorders, Dementia, Genetic Loci, Genetic Markers, Genome-Wide Association Study, Hippocampus, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide
Abstract

Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of

DOI10.1038/ng.2237
Alternate JournalNat Genet
PubMed ID22504421
PubMed Central IDPMC3427729
Grant ListHL59367 / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
P50 AG005133 / AG / NIA NIH HHS / United States
R01 AG020098 / AG / NIA NIH HHS / United States
G0901254 / MRC_ / Medical Research Council / United Kingdom
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R01 AG031287 / AG / NIA NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
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N01-HC-25195 / HC / NHLBI NIH HHS / United States
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R01 AG040770 / AG / NIA NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
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N01AG12100 / AG / NIA NIH HHS / United States
HL7825 / HL / NHLBI NIH HHS / United States
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G1100616 / MRC_ / Medical Research Council / United Kingdom
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UL1 RR025005 / RR / NCRR NIH HHS / United States
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MR/K01417X/1 / MRC_ / Medical Research Council / United Kingdom
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
G0701075 / MRC_ / Medical Research Council / United Kingdom
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HL105756 / HL / NHLBI NIH HHS / United States
R56 AG020098 / AG / NIA NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
R01 AG017917 / AG / NIA NIH HHS / United States
AG033193 / AG / NIA NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
G1001245 / MRC_ / Medical Research Council / United Kingdom
HL087652 / HL / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
HL093029 / HL / NHLBI NIH HHS / United States
R01 MH078111 / MH / NIMH NIH HHS / United States
R01 HL093029 / HL / NHLBI NIH HHS / United States
NS17950 / NS / NINDS NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
HL087641 / HL / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
AG08122 / AG / NIA NIH HHS / United States
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R01 AG008122 / AG / NIA NIH HHS / United States
AG15819 / AG / NIA NIH HHS / United States
P30 AG010161 / AG / NIA NIH HHS / United States
AG05133 / AG / NIA NIH HHS / United States
R01 AG033193 / AG / NIA NIH HHS / United States
AG031287 / AG / NIA NIH HHS / United States
/ ImNIH / Intramural NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
G0700704 / MRC_ / Medical Research Council / United Kingdom
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HL086694 / HL / NHLBI NIH HHS / United States
T32 HL007825 / HL / NHLBI NIH HHS / United States
P30AG10161 / AG / NIA NIH HHS / United States
AG16495 / AG / NIA NIH HHS / United States
AG20098 / AG / NIA NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States