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Age-related macular degeneration and long-term risk of stroke subtypes.

TitleAge-related macular degeneration and long-term risk of stroke subtypes.
Publication TypeJournal Article
Year of Publication2012
AuthorsM Ikram K, Mitchell P, Klein R, Sharrett ARichey, Couper DJ
Secondary AuthorsWong TY
JournalStroke
Volume43
Issue6
Pagination1681-3
Date Published2012 Jun
ISSN1524-4628
KeywordsAged, Aged, 80 and over, Cerebral Hemorrhage, Cerebral Infarction, Female, Follow-Up Studies, Humans, Incidence, Macular Degeneration, Male, Middle Aged, Risk Factors, Stroke, Time Factors
Abstract

BACKGROUND AND PURPOSE: We examined the relationship of age-related macular degeneration (AMD) with incident stroke, including stroke subtypes of cerebral infarction and intracerebral hemorrhage.

METHODS: We included 12 216 participants with retinal photographs taken at the third examination visit (1993-1995) from the Atherosclerosis Risk in Communities (ARIC) Study, a population-based cohort study in middle-aged persons. Images were evaluated for AMD signs according to a standardized protocol. Incident events of stroke and its subtypes were identified and validated through case record review over time.

RESULTS: AMD was diagnosed in 591 participants, of whom 576 had early and 15 late AMD. After a mean follow-up of 13.0 years (SD, 3.3), 619 persons developed an incident stroke, including 548 cerebral infarction and 57 intracerebral hemorrhages. Participants with any AMD were at an increased risk of stroke (multivariable adjusted hazard ratio, 1.51; 95% CI, 1.11-2.06) with a stronger association for intracerebral hemorrhage (hazard ratio, 2.64; 95% CI, 1.18-5.87) than cerebral infarction (hazard ratio, 1.42; 95% CI, 1.01-1.99).

CONCLUSIONS: Persons with AMD are at an increased risk of both cerebral infarction and intracerebral hemorrhage. These data provide further insight into common pathophysiological processes between AMD and stroke subtypes.

DOI10.1161/STROKEAHA.112.654632
Alternate JournalStroke
PubMed ID22535267
PubMed Central IDPMC3361598
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States