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Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study.

TitleNeutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2012
AuthorsBhavsar NA, Köttgen A, Coresh JJ
Secondary AuthorsAstor BC
JournalAm J Kidney Dis
Volume60
Issue2
Pagination233-40
Date Published2012 Aug
ISSN1523-6838
KeywordsAcute-Phase Proteins, Albuminuria, Atherosclerosis, Biomarkers, Case-Control Studies, Creatinine, Female, Hepatitis A Virus Cellular Receptor 1, Humans, Kidney Failure, Chronic, Lipocalin-2, Lipocalins, Male, Membrane Glycoproteins, Middle Aged, Prognosis, Proto-Oncogene Proteins, Receptors, Virus
Abstract

BACKGROUND: Identifying individuals at risk of chronic kidney disease (CKD) is critical for timely treatment initiation to slow progression of the disease. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) are known biomarkers of acute kidney injury, but it is unknown whether these markers are associated with incident CKD stage 3 in the general population.

STUDY DESIGN: Matched case-control study.

SETTING & PARTICIPANTS: African American and white participants from the Atherosclerosis Risk in Communities (ARIC) Study who at baseline had an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m(2) and urinary albumin-creatinine ratio ≤30 mg/g. 143 controls were matched for age, sex, and race to 143 cases of incident CKD stage 3 after 8.6 years of follow-up.

PREDICTORS: Quartile of NGAL and KIM-1.

OUTCOMES & MEASUREMENTS: Incident CKD stage 3 (eGFR

RESULTS: Both NGAL (P = 0.05) and KIM-1 levels (P

LIMITATIONS: The relatively small sample size of the study limits precision and power to detect weak associations.

CONCLUSIONS: Higher NGAL, but not KIM-1, levels were associated with incident CKD stage 3. Adjustment for urinary creatinine and albumin concentration attenuated this association. Additional studies are needed to confirm these findings and assess the utility of urinary NGAL as a marker of CKD risk.

DOI10.1053/j.ajkd.2012.02.336
Alternate JournalAm J Kidney Dis
PubMed ID22542304
PubMed Central IDPMC3399971
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
U01 HL075572 / HL / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
R01DK076770 / DK / NIDDK NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
T32 HS019488 / HS / AHRQ HHS / United States
R01 DK076770 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
U01HL075572-01 / HL / NHLBI NIH HHS / United States
T32HS019488 / HS / AHRQ HHS / United States
HHSN268201100006C / / PHS HHS / United States
T32HL07024 / HL / NHLBI NIH HHS / United States